نتایج جستجو برای: apoptosiscisplatindcr2nonsmall cell lung cancersubtoxic dosetrail

تعداد نتایج: 1875718  

Effect of trichostatin A on histone deacetylase 1 (HDAC 1) and CIP/KIP (p21CIP1/WAF1, p27KIP1, and p57KIP2) gene expression, cell growth inhibition and apoptosis induction in lung cancer COR-L105 cell line. Abstract Background: Lung cancer is one the leading cause of cancer-related death worldwide, with more than 1.2 million deaths each year. In addition to genetic mutations, epigenetic modif...

Fazel Shokri, Saeed Rajabalian, Vahideh Farahat, Zahra Samadi Bahrami,

Human diploid fibroblast cells produce a spectrum of necessary growth factors and extracellular matrix (ECM) components essential for growth and proliferation of a variety of other cell types. In this study, the effect of five human embryonic fibroblast cell lines, isolated from liver, lung, skin and foreskin tissues, was investigated. A coculture system analyse was employed to cloning efficien...

Journal: :iranian biomedical journal 0
behrooz karimi department of environmental health engineering, school of public health, tehran university of medical sciences, enghelab st., tehran, iran masud yunesian department of environmental health engineering, school of public health, tehran university of medical sciences, enghelab st., tehran, iran ramin nabizadeh department of environmental health engineering, school of public health, tehran university of medical sciences, enghelab st., tehran, iran parvin mehdipour department of medical genetics, school of medicine, tehran university of medical sciences, enghelab st., tehran, iran afsaneh aghaie high institute for research and education in transfusion medicine, tehran, iran

background: epidemiological studies have probed the correlation between telomere length and the risk of lung cancer, but their findings are inconsistent in this regard.  the present meta-analysis study has been carried out to demonstrate the association between relative telomere length in peripheral blood leukocytes and the risk of lung cancer using an established q-pcr technique. methods: a sy...

Afsaneh Aghaie, Behrooz Karimi, Masud Yunesian, Parvin Mehdipour, Ramin Nabizadeh,

Background: Epidemiological studies have probed the correlation between telomere length and the risk of lung cancer, but their findings are inconsistent in this regard.  The present meta-analysis study has been carried out to demonstrate the association between relative telomere length in peripheral blood leukocytes and the risk of lung cancer using an established Q-PCR technique. Methods:...

ژورنال: :مجله دانشکده پزشکی اصفهان 0
فهیمه حامدی دانشجوی کارشناسی ارشد ژنتیک، گروه سلولی و مولکولی، دانشکده ی علوم زیستی، دانشگاه خوارزمی، تهران، ایران محمد طهماسب استادیار، گروه سلولی و مولکولی، دانشکده علوم زیستی، دانشگاه خوارزمی، تهران، ایران عباس قادری استاد، مرکز تحقیقات سرطان، دانشگاه علوم پزشکی شیراز، شیراز، ایران

مقدمه: پلی مورفیسم ژنتیکی در ژن های درگیر در ترمیم dna ممکن است با کاهش ظرفیت ترمیمی محصولات این ژن ها، سبب افزایش خطر ابتلا به سرطان های مختلف در انسان شود. ژن xrcc1 یکی از ژن های مهم در ترمیم dna می باشد. در این مطالعه، پلی مورفیسم gln399arg در ژن xrcc1 و ارتباط آن با استعداد ابتلا به سرطان ریه در جمعیت استان فارس مورد بررسی قرار گرفت. روش ها: در این مطالعه ی مورد- شاهدی، dna استخراج شده از 1...

ژورنال: Anatomical Sciences Journal 2010
Jalali , Mahdi, Moein, Abbas Ali, Mohammadi, Shabnam, Karimfar, Mohammad Hasan, Nikravesh, Mohammad Reza,

Purpose: In this study we evaluated the effect of maternal nicotine administration during pre and postnatal period on collagen IV changes in lung of mouse newborns. Materials and Methods: Female Balb/C mice were mated and finding vaginal plug was assumed as day zero of pregnancy. Pregnant mice, were divided into 2 experimental and 2 control groups. Experimental group 1, received 3 mg/kg nicotin...

Giant cell tumour (GCT) is a benign, locally aggressive tumour of the bone that accounts for 5% of primary bone tumours and 21% of benign bone tumours. This tumour more commonly presents as a single (solitary) lesion; however, it may appear with multiple (multicentric) lesions in less than 1% of the cases. According to the literature, 1-9% of solitary GCTs metastasizes to the lung, more commonl...

ژورنال: Anatomical Sciences Journal 2010
Mirshafiei, Gholam Ali, Saberi , Mahdi, Sadraei , Seyyed Homayoun, Jafari , Mahvash, Kaka, Gholam Reza,

Purpose: The aim of this study was to evaluate the effects of HMT on protection of lung tissue exposed to HD in the rat. Materials and Methods: In this study twenty Albino Wister adult male rats weighting 200±20 gram were used. Rats divided randomly into 4 groups (each group has 5 rats) as below: Normal saline group (NS), HMT group, HD group (0.25% HD) and HD+HMT group. Normal saline and HD sol...

Lung carcinoma is the second most common type of cancer. Inefficiency of the current treatments and the undesirable side effects of chemotherapy drugs made the know-how of the treatment important. The purpose of this study is to investigate the synergic effect of curcumin and Cisplatin in comparison with the sole application of each treatment on Calu-6 cell line, an epithelial cell line of huma...

Journal: :مجله دانشگاه علوم پزشکی شهید صدوقی یزد 0
ابوالفضل برخورداری a barkhordari جان کلور j mcclure

introduction: the respiratory system is both a route of entry and exit for toxins and injurious agents, as well as being a target for chemical substances and pathogens. therefore, an understanding of the structure and function of the migratory cell populations of pulmonary tissues including alveolar macrophages is central in a number of important disease processes. this study aimed to identify ...

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