نتایج جستجو برای: apobec3
تعداد نتایج: 501 فیلتر نتایج به سال:
OBJECTIVE This study aimed to evaluate the relationships between members of APOBEC3 in tumor tissues and hepatocellular carcinoma (HCC) aggressiveness and prognosis. METHODS Using the expression profile GSE36376 from Gene Expression Omnibus (GEO), we compared APOBEC3 expression between tumor and non-tumor tissues, and correlated this with clinico-pathological features and outcomes of HCC pati...
APOBEC3 enzymes are a key source of mutagenesis in breast cancer. PI3K inhibitors currently used the treatment PIK3CA-mutated advanced However, whether specific PIK3CA mutations (muts) associated with better outcomes is unclear. We developed computational framework to screen for APOBEC3-induced within TCW context using whole-exome sequencing (WES) data from cancer cohort genome atlas (TCGA-BRCA...
PURPOSE APOBEC3 DNA cytosine deaminase family members normally defend against viruses and transposons. However, deregulated APOBEC3 activity causes mutations in cancer. Because of broad expression profiles and varying mixtures of normal and cancer cells in tumors, including immune cell infiltration, it is difficult to determine where different APOBEC3s are expressed. Here, we ask whether correl...
PURPOSE To develop methods for primary culture of human blood-retinal barrier (BRB) cells and to explore the expression of APOBEC3 (apolipoprotein B mRNA-editing enzyme, catalytic polypeptide-like 3) family gene, novel host-defense factors to HIV-1. METHODS Cellular components of human BRB (human retinal capillary endothelial cells [HRCECs], human retinal capillary pericytes, and human retina...
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