Acute promyelocytic leukemia (APL) is characterized by the specific chromosome translocation t(15;17) with promyelocytic leukemia-retinoic acid receptor-alpha (PML-RARA) fusion gene and the ability to undergo terminal differentiation as an effect of all-trans retinoic acid (ATRA). Recently, arsenic trioxide (As(2)O(3)) has been identified as an alternative therapy in patients with both ATRA-sen...

Recent studies indicate that angiogenesis is important in the pathogenesis of leukemias, apart from its well-established role in solid tumors. In this study, the possible role of angiogenesis in acute promyelocytic leukemia (APL) was explored. Bone marrow trephine biopsies from patients with APL showed significantly increased microvessel density and hot spot density compared with normal control...

Acute promyelocytic leukemia (APL) is the subtype of acute myeloid leukemia characterized by an accumulation of abnormal promyelocytes in bone marrow, a severe bleeding tendency and the presence of the chromosomal translocation t(15;17) or variants. APL, the most fatal type of leukemia two decades ago, is highly curable with current treatment strategies. There is evidence that the incidence of ...

The development of programming skills is a motivating issue in computer science. Programming languages have been increasingly used to map end-users needs and mental models. The number of users who can program or learn how to program have been expanded. The majority of these languages are focused on sighted users. This study introduces APL, an Audio Programming Language for blind learners. APL i...

PL programs have made signifi cant and continuous use of electronics technology from the very beginning. In fact, the VT fuze was a marvel of the Laboratory’s electronics technology and the ingenuity of its practitioners. Electronics technology at APL can be subdivided into fi ve broad areas: microelectronics and advanced packaging, RF and microwaves, embedded computers and programmable devices...

ehicle technology at APL encompasses the four disciplines of guidance and control, navigation, aerodynamics/hydrodynamics, and propulsion as applied to military platforms and spacecraft. These disciplines are addressed in terms of historical background at APL, the status of current work, and examples of important new initiatives. The information was compiled for the Senior Leadership Team’s “Ve...

Wastewater propagation chains (WPCs) measure inter-sector average lengths (APL) of wastewater discharge. To achieve sustainable management, one needs to understand the mechanisms by identifying WPCs at a national level over time. However, traditional model is prone retaining APLs with lower values but larger discharge intensities, ignoring many linkages whereby intensities are less than preset ...

Acute promyelocytic leukemia (APL) is currently considered to be a highly curable disease. However, early death (ED) remains a major cause of treatment failure in APL. The purpose of this study was to retrospectively review the morphological, immunophenotypic and molecular characteristics of 26 patients with APL resulting in ED. It was observed that elevated white blood cell (WBC) counts, lower...