Apelin, a peptide hormone, is an endogenous ligand for G protein-coupled receptor and has been shown to be widely expressed in human animal tissues, such as the central nervous system adipose tissue. Recent studies indicate that apelin/APJ involved regulation of multiple physiological pathological processes, it associated with cardiovascular diseases, metabolic disorders, neurological ischemia-...

We have tested a panel of pediatric and adult human immunodeficiency virus type 1 (HIV-1) primary isolates for the ability to employ the following proteins as coreceptors during viral entry: CCR1, CCR2b, CCR3, CCR4, CCR5, CCR8, CXCR4, Bonzo, BOB, GPR1, V28, US28, and APJ. Most non-syncytium-inducing isolates could utilize only CCR5. All syncytium-inducing viruses used CXCR4, some also employed ...

This month's installment of Generally Physiological considers a channel in skeletal muscle and a cardiac G pro-tein–coupled receptor (GPCR) that are sensitive to mechanical stress as well as their respective ligands, and how the geometry of subcellular domains influences GPCR dynamics. Stretching the boundaries of nAChR gating Although ion channels are often broadly classified as " voltage-gate...

Currently, there is major interest in the functions of apelin-13, an endogenous ligand for the orphan G-protein coupled receptor APJ, a receptor that closely resembles the angiotensin receptor AT1. In the present study, the role of apelin-13 in angiogenesis and its mechanism as a novel angiogenic factor in myocardial microvascular endothelial cells (MMVECs) was investigated. It was revealed tha...

Possible involvement of downregulation of the apelin–APJ system in 1 doxorubicin-induced cardiotoxicity 2 Juri Hamada , Altansarnai Baasanjav, Natsumi Ono, Kazuya Murata, Koichiro 3 Kako, Junji Ishida , Akiyoshi Fukamizu 2 4 Graduate School of Life and Environmental Sciences, Life Science Center, 5 Tsukuba Advanced Research Alliance (TARA), University of Tsukuba, 1-1-1 6 Tennodai, Tsukuba, Ibar...

Heart failure is a chronic, progressive disease in which the overexpression of biologically active molecules and neurohomonal activation are the key factors of the evolution and natural history. The apelin-APJ system is a newly discovered molecular pathway and the RAAS counterbalance is its principal effect. The apelin is a potent inotrope, vasodilator and diuretic with crucial cardioprotective...

A pilot-scale treatment system of atmospheric plasma jet (APJ) was developed and its effects on the inactivation natural bacteria in rice germ, black pepper powder, sesame were investigated. The optimal sample amount, rotary valve speed, operation time, pressure for determined to be 200 g, 40 rpm, 10 min, 0.2 MPa, respectively, which inactivated by 1.4, 1.0, 1.4 log CFU/g, respectively. Dust re...