Apigenin (4',5,7-trihydroxyflavone) is a flavonoid commonly found in many fruits and vegetables such as parsley, chamomile, celery, and kumquats. In the last few decades, recognition of apigenin as a cancer chemopreventive agent has increased. Significant progress has been made in studying the chemopreventive aspects of apigenin both in vitro and in vivo. Several studies have demonstrated that ...

Preparative reversed-phase HPLC analysis of the methanol extract of the aerial parts of Stachys bombycina (Lamiaceae) afforded two acylated flavonoids glycosides, chrysoeriol 7-O-[6-O-acetyl-beta-D-allopyranosyl]-(1 --> 2)-beta-D-glucopyranoside (1) and apigenin 7-O-beta-D-(6-p-coumaroyl)-glucopyranoside (2), the former being a new natural product. The structures of these compounds were elucida...

Quercetin is an important dietary flavonoid with putative beneficial effects in the prevention of cancer and CVD. The in vivo bioactivity of quercetin depends on its bioavailability, which varies widely between foods. We used an in situ rat intestinal perfusion model to study whether differential small intestinal hydrolysis of the sugar moiety of five naturally occurring quercetin glycosides de...

We examined whether apigenin affects the gene expression, secretion and activity of matrix metalloproteinase-3 (MMP-3) in primary cultured rabbit articular chondrocytes, as well as in vivo production of MMP-3 in the knee joint of rat to evaluate the potential chondroprotective effects of apigenin. Rabbit articular chondrocytes were cultured in a monolayer, and reverse transcription - polymerase...

This study aimed to investigate the phytochemical composition, alpha-amylase and pancreatic lipase inhibitory activities anti-inflammatory antioxidant properties of crude extracts (petroleum ether, ethyl acetate n-butanol) obtained from aerial parts Ephedra altissima. The characterization phenolic compounds in was performed by high performance liquid chromatographyphotodiode array detection-ele...

This investigation studied the effect of topical application of apigenin on skin tumorigenesis initiated by 7,I2-dimethylbenz(a)anthracene (DMBA) and promoted by 12-O-tetradecanoylphorbol-13-acetate (TPA) in SENCAR mice. Apigenin was a potent inhibitor of epidermal ornithine decarboxylase induction by TPA in a dose-dependent manner from 1 to 20 «imol. Two tumorigenesis studies were conducted. ...

A UDP glucosyltransferase from Bacillus licheniformis was overexpressed, purified, and incubated with nucleotide diphosphate (NDP) d- and l-sugars to produce glucose, galactose, 2-deoxyglucose, viosamine, rhamnose, and fucose sugar-conjugated resveratrol glycosides. Significantly higher (90%) bioconversion of resveratrol was achieved with α-d-glucose as the sugar donor to produce four different...

The seeds of Indigofera heterantha yielded a flavonoid characterized as quercetin 3-O-α-L-rhamnoside along with known 3,5,7-trihydroxy-6,4 ́-dimethoxyflavone and 3,5,4 ́-trihydroxy-6,7-dimethoxyflavone. The isolated compounds were characterized by using modern spectroscopic techniques such as UV, IR, NMR and mass.

The mature pericarp of Citri Reticulatae 'Chachi' (PCRC) is one the six traditional Chinese medicinal materials that should be used after long storage, and it was regarded longer medicine stored, better. However, aging mechanism not clear. To further investigate effect on main active flavonoids PCRC, ultra-performance liquid chromatography coupled with triple quadrupole mass spectrometry (UPLC-...

Apigenin (4',5,7-trihydroxyflavone) is an activator of cystic fibrosis transmembrane conductance regulator (CFTR)-mediated Cl(-) currents across epithelia at low concentrations and a blocker at high concentrations. We determined the roles of structural components of apigenin for both stimulation and block of Cl(-) currents across Calu-3 epithelia. The half-maximal binding affinity of apigenin f...