Evidence is presented to support the recent suggestion that human neural tube closure is similar to that observed in mice, and comprises several regionally distinct closure sites rather than being a simple zipping up process. Seven subjects, each with more than one neural tube defect (NTD), are described. Comparative studies of the location of the lesions in relation to the closed parts of the ...

We develop a propagating front analysis, in terms of a local probability of zipping, for the helicase activity of opening up a double stranded DNA (dsDNA). In a fixed-distance ensemble (conjugate to the fixed-force ensemble) the front separates the zipped and unzipped phases of a dsDNA and a drive acts locally around the front. Bounds from variational analysis and numerical estimates for the sp...

accumulation of soft tissue or dentinal remnants in the apical region is a common event that can cause blockage of root canals. this event can be avoided if apical patency is performed during the root canal shaping procedures. however, there is no consensus on the role of apical patency in relation to the success of endodontic treatment of necrotic teeth with apical periodontitis. therefore, th...

Objectives: Different chelators may be used during root canal treatment, offering various advantages including lubricant effect inside the canal and smear layer removal. However, chelator residues in narrow root canals can lead to apical microleakage. The aim of this in-vitro study was to compare apical microleakage following the use of three root canal chelators via fluid filtration method in ...

In the field of developmental biology, live imaging is a powerful tool for studying, in real time, the dynamic behaviors of tissues and cells during organ formation. Mammals, which develop in utero, have presented a challenge for live imaging. Here, we offer a novel, prolonged and robust live imaging system for visualizing the development of a variety of embryonic tissues in the midgestation mo...

purpose: the aim of this study was to compare the effects of a) a flame heated endo plugger, b) gatesglidden drills and c) gpx drills on the apical seal for the purpose of post space preparation. materials & methods: the crowns of sixty six extracted maxillary central teeth were removed from cej by a diamond disc and the root canals were prepared and obturated with guttapercha and sealer (ah26)...

statement of problem: when a tooth is treated endodontically, there are several objectives, which must be met for the root canal therapy to be successful. one of those objectives is the complete obturation of the root canal system. purpose: the purpose of this study was to evaluate the apical sealability of the theramfil endodontic obturation technique and compared it with lateral condensation....