Most applications need to invoke some Application Programming Interfaces (APIs), e.g. JDK (Java Development Kit) API. When invoking those APIs, applications must follow some API constraints. Violation of these constraints will lead to some severe program defects. To detect this kind of defects, lots of static and dynamic approaches are explored, using formally described API constraints. While m...

API-1 (pyrido[2,3-d]pyrimidines) is a novel small-molecule inhibitor of Akt, which acts by binding to Akt and preventing its membrane translocation and has promising preclinical antitumor activity. In this study, we reveal a novel function of API-1 in regulation of cellular FLICE-inhibitory protein (c-FLIP) levels and TRAIL-induced apoptosis, independent of Akt inhibition. API-1 effectively ind...

Malignant mesothelioma (MM) is a tumor arising from mesothelium. MM patients' survival is poor. The polyphenol 4',5,7,-trihydroxyflavone Apigenin (API) is a "multifunctional drug". Several studies have demonstrated API anti-tumoral effects. However, little is known on the in vitro and in vivo anti-tumoral effects of API in MM. Thus, we analyzed the in vitro effects of API on cell proliferation,...

BACKGROUND AND PURPOSE The purpose of the study is to study the nerve conductivity of the tibial motor, peroneal motor, peroneal sensory, and sural nerves in patients with primary and secondary Raynaud's phenomenon (RP). SUBJECTS Twenty each: primary RP, secondary RP, and normal controls. METHODS Electromyography using distal latency (DL) and nerve conduction velocity (NCV) as dependent var...

recently, as the result of the development in modern imaging, computerized three dimensional data processing and advanced engineering techniques, an prosthesis that match the skeletal anatomy can be accurately designed from computer aided design (cad) technique and the physical model of prosthesis or skull replica can be produced through rapid prototyping (rp), rapid tooling (rt), and computer ...

A new method was established for estimation of Bortezomib by RP-HPLC method. The chromatographic conditions were successfully developed the separation using Phenomenex Luna C18 column 250x4.6mm 5µm, flow rate 1.0 ml/min, mobile phase ratio Acetonitrile : 0.1% formic acid (50: 50 v/v),detection wavelength 280 nm. retention time found to be 5.3 mins. % purity 100.443% respectively. system suitabi...

onychomycosis due to the yeast and yeast-like fungi was investigated among the 147 patient who refered to the mycology laboratory of school of public health during the period of 11 months. the isolated yeasts and yeast-like fungi were examined by api auxanogram methed. the distribution of isolated microorganisms were c. tropicalis 10(7.4%), c.guillioimondii & (5.9%) cases and one case of each o...

This paper presents an experimental investigation on geopolymer cement formulations for enhancing oil-well integrity. Fresh slurry properties, mixability, density, free-water, and rheology were determined possible field applications. The compressive strength expansion characteristics studied the durability integrity of well system. Mix complied with requirements API RP 10B-2. All showed homogen...