Tuberculosis remains a major global health problem and alternative therapeutic approaches are needed. Considering the high prevalence of lung tuberculosis (80% of cases), the pulmonary delivery of antitubercular drugs in a carrier system capable of reaching the alveoli, being recognised and phagocytosed by alveolar macrophages (mycobacterium hosts), would be a significant improvement to current...

BACKGROUND TBM (Tuberculous meningitis) is severe form of tuberculosis causing death of one third of the affected individuals or leaving two-third of the survivors disabled. MMP-9 (Matrix metalloproteinase-9) is produced by the central nervous system in a variety of inflammatory conditions and has a role in the breakdown of extracellular matrix and blood-brain barrier. METHODS In this study, ...

Tuberculosis remains among the commonest infectious diseases in the developing world and is a major source of morbidity and mortality. Conventional treatments typically consist of long-term therapy with multiple drugs which often leads to poor patient compliance as well as adverse effects. Poor compliance is in turn a major cause for the development of multidrug resistant (MDR) tuberculosis for...

TB (Tuberculosis) is a common infectious disease affecting humans since very long time. Multidrug therapy with its associated adverse drug reactions one of the major concerns for management TB. The current study has been conducted identifying causality assessment, severity as well preventability first-line anti-tubercular agents. All diagnosed patients tuberculosis attending and chest departmen...

In the present work a novel hybrid system for delivery of two first-line antitubercular drugs, rifampicin (RIF) and isoniazid (INH), was designed. order to control release drugs improve efficiency conventional carriers, like liposomes or solid lipid nanoparticles (SLNs), new systems were developed by embedding SLNs into lecithin-based through reverse-phase evaporation method. The characterized ...

Newly emerging multi-drug resistant strains of Mycobacterium tuberculosis (M.tb) severely limit the treatment options for tuberculosis (TB); hence, new antitubercular drugs are urgently needed. The mymA operon is essential for the virulence and intracellular survival of M.tb and thus represents an attractive target for the development of new antitubercular drugs. This study is focused on the st...