Bisperoxovanadium (bpV) compounds are irreversible protein tyrosine phosphatase (PTP) inhibitors with a spectrum of activity distinct from that of vanadium salts. We studied the efficacy of a panel of bpVs as antineoplastic agents in vitro and in vivo with a view to investigating phosphatases as potential antineoplastic targets. The Cdc25A dual-specificity phosphatase is an oncoprotein required...

background:acute poisoning with organophosphorus (op) pesticides is a common method of suicide and entails considerable mortality in bangladesh. the objective of this study was to evaluate the effects and outcomes of a protocol for treatment of op poisoning that included titrated incremental atropine as loading dose and slow infusion for maintenance.  methods:in this prospective descriptive cas...

the main objective of the current study is to investigate the impacts of environmental evolutionsat global scale on iran’s environmental planning. thereby, all political movements towards solving environmental issues in iran were accurately reviewed to find out the impressibility of the events by the global environmental evolutions. the findings indicated that iran has joined the conventions an...

THE treatment of cancer by the local application of chemical substances has been practised since the time of Hippocrates. Moore, writing in the British Medical Journal of 1866, commented on the failure of occasional applications of caustic pastes in the treatment of cancer and suggested the necessity for a long continued stream of the medicinal agent flowing through the tumour. Modern chemother...

Long-term uninterrupted therapy is essential for maximizing clinical benefits of antiangiogenic drugs (AADs) in cancer patients. Unfortunately, nearly all clinically available AADs are delivered to cancer patients using disrupted regimens. We aim to develop lifetime, nontoxic, effective, orally active, and low-cost antiangiogenic and antitumor drugs for treatment of cancer patients. Here we rep...

OBJECTIVE Kaposi sarcoma is an angioproliferative disease. Kaposi sarcoma is clinicopathologically classified into four subgroups based on epidemiological data. For its systemic treatment, in addition to some chemotherapeutics, taxanes have also been used during the recent years for their anti-angiogenic properties. In this study, we aimed to compare paclitaxel and non-paclitaxel chemotherapeut...

Cancer therapies that target key molecules have not fulfilled expected promises for most common malignancies. Major challenges include the incomplete understanding and validation of these targets in patients, the multiplicity and complexity of genetic and epigenetic changes in the majority of cancers, and the redundancies and cross-talk found in key signaling pathways. Collectively, the uses of...

Oncology involves a therapeutic area with complex and individual disease states and disease progression and there is a limited number of anticancer drugs available. The drugs are usually administered in empirical complex dosing regimens which result in highly variable success rates. The following two approaches to achieve a more streamlined and rational drug development and drug treatment seem ...

BACKGROUND: Few randomized trials of preoperative and postoperative adjuvant systemic therapy have been performed in patients with non-small-cell lung cancer (NSCLC). METHODS: The authors reviewed the recent literature on comparative trials and meta-analyses to determine the current status of adjuvant therapy for patients with NSCLC. RESULTS: Postoperative adjuvant therapy with cisplatin-contai...