Fruits and derivatives, such as juices, are complex mixtures of chemicals, some of which may have mutagenic and/or carcinogenic potential, while others may have antimutagenic and/or anticancer activities. The modulating effects of honey-sweetened cashew apple nectar (HSCAN), on somatic mutation and recombination induced by ethyl methanesulfonate (EMS) and mitomycin C (MMC) were evaluated with t...

The objectives of this study were to determine the major components in tea leaves and tea extracts and to study the relationship between chemical content and antimutagenic activity of various tea extracts. The amount of catechins in various tea extracts was in the order: green tea (26.7%) > oolong tea (23.2%) > pouchong tea (15.8%) > black tea (4.3%). The amounts of caffeine and phenolic compou...

Fractions from an organic extract from fresh octopus (Paraoctopus limaculatus) were studied for biological activities such as antimutagenic and antiproliferative properties using Salmonella tester strains TA98 and TA100 with metabolic activation (S9) and a cancer cell line (B-cell lymphoma), respectively. A chloroform extract obtained from octopus tentacles was sequentially fractionated using t...

Jackfruit contains high-value biological compounds (HVBC) with important activity in the inhibition of carcinogenesis, through various mechanisms. This study aimed to identify HVBC a methanolic fraction an extract jackfruit; which was reported antimutagenic and antiproliferative against PC3 cells (prostate cancer). The profile includes 3 organic acids, 5 phenolic 12 flavonoids, 2 carotenoids. i...

Background: In recent years, there has been a surge in interest studying plant-derived materials and their impact on DNA. Herbal products include number of natural substances that may help protect cells against mutagen-induced cell damage.
 Aim: The purpose this research was to assess the genotoxic effects Cassia Auriculata Linn flavonoids (CAF) saponin (CAS) rich fractions mouse bone marr...

Several studies have reported that lactic acid bacteria may increase the production of free fatty acids by lipolysis of milk fat, though no studies have been found in the literature showing the effect of kefir grains on the composition of fatty acids in milk. In this study the influence of kefir grains from different origins [Rio de Janeiro (AR), Viçosa (AV) e Lavras (AD)], different time of st...

Natural plant extracts offer a promising hope in the prevention/treatment of cancer arising from genetic mutations. This study evaluated in vitro and in vivo mutagenic and antimutagenic effects of aqueous fraction of Myristica fragrans (AFMF) leaves on TA100 strain of Salmonella typhimurium and Mus musculus (Male Swiss albino mice), respectively. The antioxidant activity of AFMF against 2,2-dip...

Colorectal Cancer (CRC) is dangerous cancer that causes many cases of death in the world. This spike occurred 2020 with 1.15 million and expected to increase 2040 by 1.92 CRC cases. Some most popular drugs used for chemotherapy are 5-Fluorouracil, Oxaliplatin, Irinotecan. The effects caused using synthetic loss appetite, fatigue, vomiting, numbness, hair loss, low blood cell count. Anthocyanins...

Moquiniastrum polymorphum subsp floccosum (Cabrera) G. Sancho is used in traditional Brazilian medicine to treat inflammation and infection, which is supported by scientific data. However, only one study has been conducted on the mutagenic activity of the extract, which has important safety implications. This study evaluated the mutagenic/antimutagenic activity of M. polymorphum ethanolic extra...