SUMMARY AMPA is a web application for assessing the antimicrobial domains of proteins, with a focus on the design on new antimicrobial drugs. The application provides fast discovery of antimicrobial patterns in proteins that can be used to develop new peptide-based drugs against pathogens. Results are shown in a user-friendly graphical interface and can be downloaded as raw data for later exami...

Recognizing the importance of antimicrobial resistance and the need for veterinarians to aid in efforts for maintaining the usefulness of antimicrobial drugs in animals and humans, the Board of Regents of the American College of Veterinary Internal Medicine charged a special committee with responsibility for drafting this position statement regarding antimicrobial drug use in veterinary medicin...

  Objective(s):   The ongoing increasing antibiotic resistance is one of the biggest challenges faced by global public health. The perennial need for new antimicrobials against a background of increasing antibiotic resistance in pathogenic and opportunistic microorganisms obliges the scientific community to constantly develop new drugs and antimicrobial agents. Lichens are known pro...

In Hospitals William Jarvis, Centers for Disease Control and Prevention (CDC), discussed antimicrobial resistance related to hospitalization. Two major factors contribute to the emergence and spread of antimicrobial resistance in hospitals: a high rate of antimicrobial drug use and inadequate infection control practices. Much antimicrobial drug use in hospitals is inappropriate (e.g., the use o...

BACKGROUND There is universal awareness of the difficulties faced by doctors when prescribing antimicrobials. METHODS Over a six-month period patients hospitalized in the ICU and under treatment with antibiotics and/or antifungals were eligible to participate in the study. The data were assessed by two infectious diseases specialists. Once completed, all case forms were sent independently to ...

ANTIBIOTICS Fluoroquinolones The fluoroquinolone class of antibiotics work via inhibition of DNA gyrase (topoisomerase II). Resistance is mediated through chromosomal mutations in DNA gyrase which confers cross-resistance to other FQs. FQs distribute well to tissues and intracellularly. Elimination is via the kidney, and these drugs are often highly effective for treating resistant UTIs. The sp...

1 Graduate Program in Life Sciences, Microbiology and Immunology Program, School of Medicine, University of Maryland, Baltimore, Maryland, United States of America, 2 Department of Microbial Pathogenesis, Dental School, University of Maryland, Baltimore, Maryland, United States of America, 3 Department of Microbiology and Immunology, School of Medicine, University of Maryland, Baltimore, Maryla...

Antimicrobial peptides (APs) are an important part of the innate immune system in epithelial and non-epithelial surfaces. So far, many different antimicrobial peptides from various families have been discovered in non-vertebrates and vertebrates. They are characterized by antibiotic, antifungal and antiviral activities against a variety of microorganisms. In addition to their role as endogenous...

Three antimicrobial nitroimidazole drugs (metronidazole, dimetridazole, and tinidazole) inhibit a range of clostridia and the protozoan Trichomonas vaginalis ; they have an identical site and mode of action as specific electron acceptors from the pyruvate phosphoroclastic reaction. Analogues of the drugs are compared and the structural requirements for activity explained. The nitrofuran (nitrof...

Given that: (1) the worldwide consumption of antimicrobial drugs (AMDs) used in food-producing animals will increase over the coming decades; (2) the prudent use of AMDs will not suffice to stem the rise in human antimicrobial resistance (AMR) of animal origin; (3) alternatives to AMD use are not available or not implementable, there is an urgent need to develop novel AMDs for food-producing an...