The exceptional diversity of the genus Rhododendron has a strong potential for identification, characterization, and production of bioactive lead compounds for health purposes. A particularly relevant field of application is the search for new antibiotics. Here, we present a comparative analysis of nearly 90 Rhododendron species targeted toward the search for such candidate substances. Through ...

INTRODUCTION Three series of pyrazole, thiazole and 1,3,4-oxadiazole, derivatives were synthesized starting from 5-amino-4-(hydrazinocarbonyl)-3-methylthiophene-2-carboxamide (2). METHODS All compounds were investigated for their preliminary antimicrobial activity. They were proved to exhibit remarkable antimicrobial activity against Pseudomonas aeruginosa with insignificant activity towards ...

The antimicrobial effects of diethanolamine, dimethylamino-methyl-propanol, and butylethanolamine are greatly enhanced at high pH. Their antimicrobial activities are closely correlated with their uncharged forms, indicating that diffusion through cell membrane(s) is rate limiting for the antimicrobial action. Since these compounds are selectively toxic at high pH, they are appropriate antimicro...

some new 3-[(5-benzylidene-2-phenyl)-3, 5-dihydro-4-h-imidazol-4-one-3-(4-bezoylhydrazono)]-indole-2-ones (viii) have been synthesized from different isatinhydrazones (ii) by condensing with 2-phenyl-5-benzylidene- 3-n (4-acetyl phenyl)-1, 5-dihydro-imidazol-4-one (vii). their chemical structures have been confirmed by ir, 1hnmr, mass and by elemental analysis. investigation of antimicrobial ac...

BACKGROUND To isolate plant-derived compounds with antimicrobial activity from the leaves of Mikania micrantha, to determine the compounds configuration, and to evaluate their antimicrobial activity against eight plant pathogenic fungi (Exserohilum turcicum, Colletotrichum lagenarium, Pseudoperonispora cubensis, Botrytis cirerea, Rhizoctonia solani, Phytophthora parasitica, Fusarium solani, and...

This article presents a complete and detailed study of synthesis, structural characterization, and possible applications of a new family of azanaphthoquinones as antimicrobial agents. A series of (alkoxy)phenylamino-chloro-2-methylquinoline-5,8-dione derivatives (3a-j, 3a', 3e') was prepared by regioselective nucleophilic substitution of 6,7-dichloro-2-methylquinoline-5,8-dione (1) with (alkoxy...

The organic extract of liquid cultures of the marine-derived Penicillium sp. was investigated. Fractionation of the extracts of the fungus led to the purification and identification of two new compounds, penicillatides A (1) and B (2), together with the previously reported cyclo(R-Pro-S-Phe) (3) and cyclo(R-Pro-R-Phe) (4). The structures of compounds 1-4 were assigned by extensive interpretatio...

A series of 1-substituted 2, 4, 5 triphenyl imidazoles were synthesized by the reaction equimolar mixture of 2, 4, 5 triphenyl imidazole with chloro compound in the presence of anhydrous potassium carbonate. The newly synthesized compounds were characterized on the basis of UV, IR and H NMR spectra. The synthesized compounds were screened for antiinflammatory, antimicrobial activities. Antiinfl...

5-(p-Substituted phenyl)-N-(3-(5-nitrofur-2-yl)allylidene)-1,3,4-thiadiazol-2-amines 10-17 were prepared utilizing different p-substituted benzoic acid through two step reactions. Firstly, thiosemicarbzide was reacted with benzoic acid derivatives 1 in the presence of phosphorus oxychloride to give 2amino-5-substituted-1,3,4-thiadiazoles 2-9. These compounds were reacted with 5-nitro-2-furanacr...