Short term inhibitor treatment can be used to examine the processes that occur during an inductive dark period in the short day plant Lemna perpusilla Torr., strain 6746. Several inhibitors of protein biosynthesis are most effective in reducing per cent flowering when treatment occurs over the 2-hour intervals beginning at the 12th hour or the 14th hour of a 8 (16) photoperiodic cycle. The anti...

Taking into account the special role of oxidative stress that increases during cancer chemotherapy, effect antioxidant emoxipine on peripheral blood mononuclears was studied under conditions simulate cytotoxic effects antimetabolites a number modified cytidine nucleosides in relation to tumor cell line K562. Lymphoid cells were also source for subsequent modelling immune response cancer. It fou...

Acute leukaemia was formerly a rapidly fatal disease, but in the past decade treatment with corticosteroids and antimetabolites has enabled life to be prolonged for many months and remissions can be obtained in the majority of cases, especially in children. Nevertheless survival for more than two years after diagnosis still remains exceptional, and the following two cases of unusually prolonged...

Ulcerative colitis is a chronic inflammatory disorder of unknown etiology. Despite current treatments that include aminosalicylates, corticosteroids, antimetabolites and TNF antagonists, many patients fail to respond to conventional medical management and undergo colectomy. Thus, new approaches to treatment are needed. This review discusses the emerging role of vedolizumab, a humanized monoclon...

1. It was found that steroid-mediated nicotinamide-adenine dinucleotide (phosphate) transhydrogenases can be inhibited in vitro by folic acid and its antimetabolites. The most potent inhibitor was methotrexate, a drug with a high therapeutic index against experimental cancer. 2. The inhibitions produced by a combination of folic acid and the analogues were additive, as were those between the fo...

sequent studies included heavy metals, dyes, metabolites and antimetabolites, hormones and vitamins, mitotic poisons and carcinostatic agents. Results ob tained in these investigations will be reviewed more extensively elsewhere (18). The present study was undertaken to examine the possible additive or synergistic effects of selected chemicals on animal tumors, when administered in combination ...