At the end of the 19th century, after having long neglected sanitary conditions in rural areas, Argentinean public health authorities began to recognize the need to combat malaria in the country's northern provinces. The disease was proliferating among workers in the sugarcane and cotton industries, jeopardizing national and international economic interests. The crusade against malaria involved...

Anopheles gambiae is a primary vector of Plasmodium falciparum, a human malaria parasite that causes over a million deaths each year in sub-Saharan Africa. Population genetic tests have been employed to detect natural selection at suspected A. gambiae antimalaria genes, but these tests have generally been compromised by the lack of demographically correct null models. Here, we used a coalescent...

Plasmodium falciparum is a global problem resulting in considerable morbidity and mortality [1,2]. Plasmodium vivax also causes appreciable morbidity and has become chloroquine – resistant in some endemic areas [3,4]. Therefore, the accurate diagnosis of malaria in febrile patients is essential for optimal patient management and the rational use of antimalaria drugs in malaria control programs....

Hydroxychloroquine (HXQ) sulphate is a synthetic antimalaria drug that is widely used in rheumatology due to its immunosuppressive properties. Delayed-type sensitization to this drug is rare. A 47-year-old woman diagnosed with HLA B27 ankylosing spondylitis was treated with HXQ for 22 days and had to discontinue the drug due to gastric intolerance. Five days later the patient developed erythema...

Diabetes melitus merupakan penyakit kronis gangguan metabolisme yang ditandai dengan hiperglikemia dan karbohidrat, dimana kurangnya sekresi insulin berjumlah 90-95% terdiagnosis tipe dialami oleh sebagian besar penderita diabetes melitus. Strategi dalam menangani antidiabetes adalah mencari senyawa baru pada tumbuhan obat. Tumbuhan cep-cepan (Castanopsis costata) famili Fagaceae sering digunak...

Each year, infections with the protozoan parasite Plasmodium falciparum kill 1 million people, mostly children in Africa. Intermittent preventive treatment (IPT) with sulfadoxine-pyrimethamine (SP) reduces the incidence of malaria and aims to prevent mortality in infants, children, and pregnant women. There is contradictory evidence as to whether this strategy may generate additional protection...

Malaria parasite metabolizes hemoglobin and detoxifies the resulting toxic ferriprotoporphyrin IX by polymerization into a crystal insoluble pigment, known as hemozoin. A polymer identical to hemozoin, β-hematin, can be obtained in vitro from hematin at acidic pH. Quinoline-containing antimalarials (e.g. chloroquine) inhibit the formation of polymer. Thus, heme polymerization is an essensial an...