نتایج جستجو برای: antifungals
تعداد نتایج: 1520 فیلتر نتایج به سال:
Topical application of antifungals does not have predictable or well-controlled release characteristics and requires reapplication to achieve therapeutic local concentration in a reasonable time period. In this article, the efficacy of five different US Food and Drug Administration-approved antifungal-loaded (amphotericin B, natamycin, terbinafine, fluconazole, and itraconazole) electrospun gel...
Malassezia globosa cytochromes P450 CYP51 and CYP5218 are sterol 14α-demethylase (the target of azole antifungals) and a putative fatty acid metabolism protein (and a potential azole drug target), respectively. Lanosterol, eburicol and obtusifoliol bound to CYP51 with Kd values of 32, 23 and 28 μM, respectively, catalyzing sterol 14α-demethylation with respective turnover numbers of 1.7 min(-1)...
BACKGROUND Onychomycosis is a difficult-to-treat infection whose current treatment paradigm relies primarily on oral antifungals. The emergence of new topical drugs broadens the therapeutic options and prompts a re-evaluation of the current Canadian treatment strategy. OBJECTIVE To define a patient-centred Canadian treatment strategy for onychomycosis. METHODS An expert panel of doctors who...
The incidence of candidemia--a common and potentially fatal nosocomial infection--has risen dramatically, and this increase has been accompanied by a shift in the infecting pathogen away from Candida albicans to treatment-resistant non-albicans species. Prophylactic azole antifungals, such as fluconazole, may play an important role not only in the management of candidemia but also in the prolif...
CURRENT SCIENCE, VOL. 85, NO. 12, 25 DECEMBER 2003 1693 *For correspondence. (e-mail: [email protected]) 64. Iso, M., Chen, B., Eguchi, M., Kudo, T. and Shreshtha, S., Production of biodiesel fuel from triglycerides and alcohol using immobilized lipase. J. Mol. Catal. B, Enzymes, 2001, 16, 53–58. 65. Nakanishi, K. and Matsuno, R., Continuous peptide synthesis in a water-immiscible o...
We performed a randomized trial to compare the safety and efficacy of itraconazole with fluconazole in preventing fungal infections in patients undergoing allogeneic stem cell transplantation (SCT). Itraconazole (intravenous 200 mg daily, or oral solution 2.5 mg/kg 3 times daily) and fluconazole (intravenous or oral, 400 mg daily) were administered with the start of conditioning therapy, until ...
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