نتایج جستجو برای: antifungal effect

تعداد نتایج: 1662710  

2014
Daniel González-Tokman Jasmin Ruch Tamara Pulpitel Fleur Ponton

Animals living in groups face a high risk of disease contagion. In many arthropod species, cuticular antimicrobials constitute the first protective barrier that prevents infections. Here we report that group-living spiders produce cuticular chemicals which inhibit fungal growth. Given that cuticular antifungals may be costly to produce, we explored whether they can be modulated according to the...

Journal: :Journal of chemotherapy 1997
E Cenci A Mencacci G Del Sero C Fé d'Ostiani C Montagnoli A Bacci F Bistoni L Romani

Resistance or susceptibility to disseminated and mucosal Candida albicans infections in mice correlates with the development of protective or nonprotective T helper (Th) cell responses. To determine whether immunomodulatory activity on Th cell functions is an effect beyond that provided by antifungal therapy, mice with disseminated or gastrointestinal infection were treated with amphotericin B ...

2012
Maqsood Ahmad Malik Shaeel Ahmed Al-Thabaiti Manzoor A. Malik

Azoles are generally fungistatic, and resistance to fluconazole is emerging in several fungal pathogens. In an attempt to find novel azole antifungal agents with improved activity, a series of tetrazole ring bearing acylhydrazone derivatives were synthesized and screened for their in vitro antifungal activity. The mechanism of their antifungal activity was assessed by studying their effect on t...

Journal: :Molecules 2017
Xiang Yu Ya Wen Chao-Gen Liang Jia Liu Yu-Bin Ding Wei-Hua Zhang

A series of linear furanocoumarins with different substituents have been designed and synthesized. Their structures were confirmed by ¹H-NMR spectroscopy, high resolution mass spectra (EI-MS), IR, and X-ray single-crystal diffraction. All of the target compounds were evaluated in vitro for their antifungal activity against Rhizoctorzia solani, Botrytis cinerea, Alternaria solani, Gibberella zea...

2016
Seung-Bae Lee

OBJECTIVES The purpose of this study was to investigate the antifungal effect of bee venom (BV) and sweet bee venom (SBV) against Candida albicans (C. albicans) clinical isolates. METHODS In this study, BV and SBV were examined for antifungal activities against the Korean Collection for Type Cultures (KCTC) strain and 10 clinical isolates of C. albicans. The disk diffusion method was used to ...

Journal: :International journal of clinical and experimental medicine 2015
Xiaolong Tang Ronghong Jiao Chunmei Xie Lifa Xu Zhen Huo Jingjing Dai Yunyun Qian Weiwen Xu Wei Hou Jiang Wang Yong Liang

To develop amphotericin B-loaded biodegradable TPGS-b-(PCL-ran-PGA) nanoparticles (PLGA-TPGS-AMB NPs) for fungal infection treatment, PLGA-TPGS NPs and PLGA NPs were synthesized by a modified double emulsion method and characterized in terms of size and size distribution, morphology and zeta potential. Drug encapsulation efficiency, in vitro drug release, and in vitro/vivo tests against Candida...

Atul Srivastava Naga Kumar Varma, Riyaz Ali M shivakumar HG, umme hani,

The present investigation was designed to formulate a natural tablet for the treatment of vaginal candidiasis in order to eliminate side effects that are caused by existing antifungal drugs. Curcumin has promising antifungal activity in comparison with the existing azole antifungal drugs. Bioadhesive curcumin vaginal tablets were prepared by direct compression with different ratios of biadhesiv...

ژورنال: Medical Laboratory Journal 2013
Doudi, M, Naghsh, N, Safaeinejad, Z,

Abstract Background and objective: In recent years, the resistance of opportunistic fungal strains to commercially available antifungal agents has been increased. The serious side effects of these compounds on mammalian cells forced the researchers to search for new antifungal substances. Thus we decided to investigate the antifungal properties of silver nanoparticles against Aspergillusfumiga...

A Bahrampour A Kariminik B.SH Ali N.D Sodir

There are many reports about antifungal and antimicrobial effects of Myrtle extract. In respect to resistance of fungal strains to current antifungal drugs such as imidazole derivatives, a comparative study was carried out to Investigate the antifungal effect of Myrtle extract versus clotrimazole on candida albicans, the most common cause of vaginal candidiasis . The vaginal discharge of 500 pa...

2015
Richard A. Pollak William J. Jo Siu Yoshiyuki Tatsumi Radhakrishnan Pillai

To provide an adequate therapeutic effect against onychomycosis, it has been suggested that topical drugs should have two properties: drug permeability through the nail plate and into the nail bed, and retention of their antifungal activity in the disease-affected areas. Only recently has the importance of other delivery routes (such as subungual) been discussed. Efinaconazole has been shown to...

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