1. dept. of biology, science and research branch, islamic azad university, tehran, iran 2. national science foundation (insf), tehran, iran 3. dept. of genetics, tehran medical sciences branch, islamic azad university, tehran, iran                                   corresponding author: mrhrdad hashemi, phd; associate professor of molecular genetics tel: (+98) 2122006664 email: mhashemi@iautmu....

Antimicrobial peptides, a large class of molecules synthetized by various organisms as an innate defense against pathogens are more and used for their anticancer properties well. In order to overcome some limitations enhance therapeutic efficiency, the use delivery systems was taken into consideration. this study we describe original system antimicrobial peptides based on its physico-chemical p...

Despite tremendous advances in cancer treatment and survival rates, pancreatic cancer remains one of the most deadly afflictions and the fourth leading cause of cancer deaths in the world. Matrix Metalloproteinases (MMPs) are thought to be involved in cancer progression. Matrix metalloproteinase (MMP)-2 is known to play a pivotal role in tumor invasion, metastasis and angiogenesis, and validate...

Tumor-homing peptides with tissue-penetrating properties increase the efficacy of targeted cancer therapy by delivering an anticancer agent to the tumor interior. LyP-1 (CGNKRTRGC) and iRGD (CRGDKGPDC) are founding members of this class of peptides. The presence of the cysteines forming the cyclizing disulfide bond complicates conjugation of these peptides with other molecules, such as drugs. H...

The present review article explains the salient features of hornet venom toxins, their physiological, biological and pharmacological effect on animals man. Hornets sting very fast inflict venom, which is more dangerous than those bees. Hornet contains both proteinaceous non-proteinaceous peptides i.e. scapin, adolapin, mellitin, mastoparans enzymes, mainly phospholipase hyaluronidase, show mult...

Non-communicable diseases (NCD) are the leading cause of death and disability worldwide. The four main leading causes of NCD are cardiovascular diseases, cancers, respiratory diseases and diabetes. Recognizing the devastating impact of NCD, novel prevention and treatment strategies are extensively sought. Marine organisms are considered as an important source of bioactive peptides that can exer...

Fish is a potential source of various forms bioactive compounds. It can be used as specific proteins, especially in medicine. Recently, studies related to the use antimicrobial peptides (AMPs) from fish are being carried out find an alternative cure for cancer. To achieve this objective, AMP must meet condition where it possesses ability target tumor cells without affecting normal cell. Therefo...