BACKGROUND Drug interactions can have a significant impact on the response to combinatorial therapy for anticancer treatment. In some instances these interactions can be anticipated based on pre-clinical models. However, the anticipation of drug interactions in the clinical context is in general a challenging task. METHODS Here we propose the pooled analysis of clinical trials as a mean to in...

Fabrication, Physicochemical Characterization and Evaluation of In vitro Anticancer Efficacy a Novel pH Sensitive Polymeric Nanoparticles for Efficient Delivery Hydrophobic Drug against Colon CancerManikandan Mahalingam, Kannan Krishnamoorthy

The present study deals with the synthesis andfunctionalization of mesoporous silica nanoparticles as drug delivery platforms. SBA-15 nanorods with high surface area (1010 m2g-1) were functionalized by post grafting method using 3-mercaptopropyl trimethoxysilane (MPTS). The parent and thiol-functionalized SBA-15 nanorods were used as nanocarriers for an anticancer drug (gemcitabine). The charac...

Around the world, tremendous resources are being invested in prevention, diagnosis, and treatment of cancer. Cancer is the second leading cause of death in Europe and North America. Discovery and development of anticancer agents are the key focus of several pharmaceutical companies as well as nonprofit government and non-government organizations, like the National Cancer Institute (NCI) in the ...

Nanomaterials are being vigorously investigated for their use in anticancer drug delivery regimes or as biomarkers agents and are considered to be a candidate to provide a way to combat severe weaknesses of anticancer drug pharmacokinetics, such as their nonspecificity. Because of this weakness, a bigger proportion of the drug-loaded nanomaterials flow toward healthy tissues and result in undes...

Abstract Drug delivery is one of the major issues in the world of science, which receives a large part of the research in various fields. The ultimate goal of drug delivery is to help the patient with developing advanced drug delivery systems. These systems revolutionize the treatment of many diseases including cancer. Effective drug carriers can significantly reduce the undesirable side effec...

PURPOSE Livin is associated with drug response in several cancers. The aim of this study was to investigate the effect of silencing the livin gene expression on anticancer drug response in colorectal cancer. METHODS siRNA was transfected at different concentrations (0, 10, and 30nM) into HCT116 cells, then cells were treated with either 5-fluorouracil (FU)/leucovorin (LV) or oxaliplatin (L-OH...

Cancer is the second leading cause of death worldwide. There always a huge demand for novel anticancer. New series pyrazole, pyridine, thiazole derivatives containing sulfonamide moiety were prepared and screened their antitumor activity against breast cancer cell line (MCF-7). The results this investigation revealed that compounds 3 8 had significant anticancer MCF-7 with IC50 values 19.2 14.2...

Most current anticancer agents present lack of specificity, leading to systemic toxicity and adverse effects, and limiting the maximum dose of drug. Liposomes quickly passed from a simple scientific curiosity to “magic bullets” for the delivery of drugs. Liposomal formulations of anticancer drugs have been extensively evaluated, with notorious advances and the market introduction of some of the...

Medicinal inorganic chemistry has been stimulating largely by the success of the anticancer drug, cisplatin. Various metal complexes are currently used as therapeutic agents (e.g., Pt, Au, and Ru) in the treatment of malignant diseases, including several types of cancers. Understanding the mechanism of action of these metal-based drugs is for the design of more effective drugs. Proteomic approa...