Pseudomonas Quinolone Signal Modulates Cystic Fibrosis Epithelial Cell Response through the TollLike Receptor 4 Patricia R. Wardwell1,2, David R. Wilson1,2, Dewayne L. Garner1,2 and Rebecca A. Bader1,2* 1Department of Biomedical & Chemical Engineering, Syracuse Biomaterials Institute, Syracuse University, Syracuse, NY, USA 2Onondaga Community College, Syracuse, NY, USA SOJ Immunology Open Acces...

The urinary antibacterial drugs enoxacin and norfloxacin were compared for efficacy and side effects in the treatment of lower urinary tract infections. Thirty-five patients received enoxacin and 25 received norfloxacin for one week. The antibacterial spectrum of enoxacin was noted to be better than that of norfloxacin, but both drugs performed well in clearing the infections caused by suscepti...

The antibacterial spectrum of besifloxacin, a novel fluoroquinolone recently approved for treatment of ocular infections, was studied using 2,690 clinical isolates representing 40 species. Overall, besifloxacin was the most potent agent tested against gram-positive pathogens and anaerobes and was generally equivalent to comparator fluoroquinolones in activity against most gram-negative pathogen...

Oral biofilms are associated with the most common infections of the oral cavity. Bacteria embedded in the biofilms are less sensitive to antibacterial agents than planktonic bacteria are. Recently, an antibacterial synergic effect of noncoherent blue light and hydrogen peroxide (H(2)O(2)) on planktonic Streptococcus mutans was demonstrated. In this study, we tested the effect of a combination o...

Infections caused by multidrug-resistant bacteria, such as methicillin-resistant Staphylococcus aureus (MRSA), have become a public threat; therefore, development of new antimicrobial drugs or strategies is urgently required. In this study, a new antibacterial peptide DP7-C (Chol-suc-VQWRIRVAVIRK-NH2) and DP7-C-modified azithromycin (AZT)-loaded liposomes (LPs) are developed for the treatment o...

UNLABELLED The oral cavity possesses a diverse microflora, yet recurrent infections within healthy individuals are rare. Wound healing within the buccal mucosa is preferential, potentially because of the presence of oral mucosal lamina propria-progenitor cells (OMLP-PCs). In addition to their multipotency, OMLP-PCs demonstrate potent immunosuppressive properties. The present study investigated ...

Cancer treatment options have evolved to include immunotherapy and targeted therapy, in addition traditional chemoradiation. Chemoradiation places the patient at a higher risk of infection through myelosuppressive effect. High clinical suspicion early use antimicrobials play major role decreasing any associated morbidity mortality. This has led widespread cancer patients. Antimicrobial use, how...

Staphylococcus aureus (S. aureus) strains with multiple antibiotic resistances are increasingly widespread, and new agents are required for the treatment of S. aureus. Cryptotanshinone (CT), a major tanshinone of medicinal plant Salvia miltiorrhiza Bunge, demonstrated effective in vitro antibacterial activity against all 21 S. aureus strains tested in this experiment. Affymetrix GeneChips were ...