The pharmacokinetics of the quinolone enoxacin were studied after a 600-mg oral dose was given to each of six male volunteers. The levels of the compound were measured in serum, blister fluid, and urine. Absorption was variable, with peak levels (mean, 3.7 micrograms/ml) being attained between 0.75 and 3.0 h (mean, 1.9 h). The serum elimination half-life was 6.2 h, and 71.6% of the drug was rec...

Antibacterial resistance poses a significant threat to human and animal health global food security. Surveillance for on farms is important many reasons, including tracking impacts of interventions aimed at reducing the prevalence resistance.

OBJECTIVES To explore patient, caregiver and physician perceptions and attitudes regarding the balance of benefit and risk in using antibacterial drugs developed through streamlined development processes. DESIGN Semistructured focus groups and in-depth interviews were conducted to elicit perceptions and attitudes about the use of antibacterial drugs to treat multidrug-resistant infections. Pa...

INTRODUCTION ...... . CHEMISTRy ...... . 199 200 RELATIONSHIPS BETWEEN CHEMICAL STRUCTURE AND ANTIBACTERIAL ACTIVITY.. 202 MECHANISM OF ANTIBACTERIAL ACTION. . . . . . . . 205 Activity 0/1 whole cells. . . . . . . . . .. . . . . . . . . . . 205 Activity Oil DNA-depelldellf RNA polymerase. 205 MUTATION TO RIFAMPICIN RESISTANCE. . . . . . 206 EFFECTS ON PHAGES AND PLASMlDS. . . . . . 208 STUDIES ...

Streptococcus pneumoniae is the major bacterial cause of pneumonia, meningitis and otitis media, and continues to be associated with significant morbidity and mortality in individuals both in the developed and developing world. Management of these infections is potentially complicated by the emergence of resistance of this pathogen to many of the commonly used first-line antimicrobial agents. A...

The antibiotic resistance patterns of aetiological agents responsible for vibriosis and pasteurellosis were studied to contribute to control the spread of these two bacterial diseases in Mediterranean fish farming. Strains of Photobacterium damsela ssp. piscicida, Vibrio fluvialis, Vibrio alginolyticus, Vibrio parahaemolyticus, Vibrio metschnikovii, isolated from Italian aquaculture (fish, shel...

Currently antimicrobial resistance among bacteria, viruses, parasites, and other disease-causing organisms is a serious threat to infectious disease management globally. Antibiotics were discovered in the middle of the nineteenth century and brought down the threat of infectious diseases which had devastated the human race. However, soon after the discovery of penicillin in 1940, a number of tr...

background: despite the discovery of numerous antibiotics, drug resistance still remains as a major problem. therefore, it is important to introduce and replace new sources of drug such as medicinal plants with antimicrobial properties. objective: the genus clematis (ranunculaceae family) has six species in iran. aerial parts of clematis have been used to cure fever and chronic diseases such as...

BACKGROUND Implant-related infections represent one of the most severe complications in orthopaedics. A fast-resorbable, antibacterial-loaded hydrogel may reduce or prevent bacterial colonization and biofilm formation of implanted biomaterials. QUESTIONS/PURPOSES We asked: (1) Is a fast-resorbable hydrogel able to deliver antibacterial compounds in vitro? (2) Can a hydrogel (alone or antibact...