recent studies have established that sex hormones directly or indirectly affect t and b cells and macrophages by manipulating the production of cytokines. in this study the possibility of the effect of 5a-dht on macrophage (mφ) nitric oxide (no) release via interleukin-l, 6 (ll-1β, il-6) or tumor necrosis factor-a (tnfα) was investigated. the endogenous cytokines il-1β, il-6 and tnf-α were neut...

Abstract Background Immune checkpoint blockade (ICB)-based cancer immunotherapy presents promising efficacy in treatment. However, only a small portion of patients show responsiveness to the treatment, which is partially caused by limited tumor infiltration T cells. Chemokines CXCL9, CXCL10 and CXCL11 bind their receptor CXCR3 regulate cell invasion. Methods We delivered plasmids encoding cells...

Isolation and identification of some potent anti-tumor compounds from medicinal plants, has motivated researchers to screen different parts of plant species for anti-tumor effects. It has been reported that several conifer posses cytotoxic activities on some human tumor cell lines. In this study, male and female branchlets or fruit of four different species of Iranian conifers (Juniperus Sabina...

Rhodiola rosea is a genus of in the family Rosea, and top-quality medicine for strengthening tonic deficiency. Modern research has found that various pharmacological effects such as anti-fatigue, anti-oxidant, anti-aging, anti-inflammatory anti-tumor. As main active ingredient rosea, Salidroside can exert anti-tumor by inhibiting tumor cell proliferation, migration, promoting apoptosis, inducin...