The objective: to determine the frequency of resistance Mycobacterium tuberculosis (MTB) most effective anti-tuberculosis drugs in patients Republic Karelia, characterize cases amplification MTB drug during chemotherapy (CT). Subjects and Methods. cultures 1,137 were studied, received from 2016 2021, among them 634 (55.8%) had multiple (MDR). Among MBT with MDR, there was a high extensive (XDR)...

Multi-drug resistant tuberculosis (MDRTB) is defined as a strain of Mycobacterium tuberculosis with resistance to at least isoniazid (H) and rifampicin (R), the two key drugs in TB treatment. Very recently, extensively drug-resistant tuberculosis (XDRTB) has gained notoriety and is defined as MDRTB with additional resistance to any fluoroquinolone, and to at least one of three injectable second...

Mycobacterium tuberculosis (MTB), an acid-fast aerobic bacterium that may grow on gram stain as either a gram-positive or gram-negative bacterium, is the disease-causing agent of (TB). Rifampin, isoniazid, pyrazinamide and ethambutol, first-line anti-tubercular drugs, can all have hepatotoxic side effects. The new medicine needs to work through novel mode action target, be more active than pres...

The tuberculosis treatment control program is constrained by the outbreak of TB that resistant to anti-tuberculosis drugs (OAT), especially multidrug-resistant tuberculosis. Confirmation drug resistance really needs be done in each area considering there are variations phenotypes and genotypes region through laboratory tests such as molecular biology tests. Aim study determine prevalence Mycoba...

This study investigated biological characteristics of recovered stressed M. tuberculosis isolates that failed to grow in differential culture media for phenotypic identification and in culture media containing anti-tuberculosis drugs for drug-susceptibility testing, despite of having grown in primary culture. It represents an improvement in the diagnosis of MDR tuberculosis and tuberculosis con...

BACKGROUND & OBJECTIVES The N-acetyltransferase 2 (NAT2) gene encodes an enzyme which both activates and deactivates arylamine and other drugs and carcinogens. This study was aimed to investigate the role of NAT2 gene polymorphism in anti-tuberculosis drug-induced hepatotoxicity (DIH). METHODS In this prospective study, polymerase chain reaction-restriction fragment length polymorphism result...

hepatic toxicity is the most serious adverse effect of anti tuberculosis drugs. this study was performed to evaluate efficacy of silymarin as a hepatoprotective herbal agent. in a randomized double blind clinical trial 70 new cases of pulmonary tuberculosis were divided into two groups. the intervention group was assigned to receive silymarin and the control group received placebo. tuberculosis...

OBJECTIVE To determine the efficacy of our modified anti-tuberculosis regimen in adult patients with multi-drug-resistant tuberculosis (MDR-TB) in the re-treatment category. METHODS Retrospective chart review of 176 patients in re-treatment category with diagnosis of MDR-TB from 1st Jan 1993 to 31st Dec 2002 managed at the Department of Pulmonology Military Hospital Rawalpindi, Pakistan. All ...

Posterior spinal tuberculosis is rare. A case of posterior spinal tuberculosis with large abscess without any neurological deficit was managed conservatively. He was relieved of pain and swelling subsided completely on anti-tubercular drugs