Purpose: To synthesize and characterize palmitoyl amino benzamides, and to evaluate them for possible anti-inflammatory and anti-nociceptive activities. Methods: Palmitoyl amino benzamides were synthesized by the opening of isatoic anhydride ring with respective amino acids (glycine, β-alanine and γ-aminobutyric acid) and the condensation of the product with palmitoyl chloride. The final produc...

BACKGROUND Chronic idiopathic pain syndromes are major causes of personal suffering, disability, and societal expense. Dietary n-6 linoleic acid has increased markedly in modern industrialized populations over the past century. These high amounts of linoleic acid could hypothetically predispose to physical pain by increasing the production of pro-nociceptive linoleic acid-derived lipid autacoid...

Lemongrass (Cymbopogon citratus) is a Poaceae family perennial grass that yields essential oil. The prefix ‘lemon’ refers to the odour, which mostly owing presence of citral, cyclic monoterpene. It rapidly growing and native South India Sri Lanka now widely cultivated throughout tropical America Asia. oil used medicinally derived from freshly cut slightly dried leave. has recently gained global...

AIMS The present study aimed to investigate the potential anti-inflammatory and anti-nociceptive effects of carvacryl acetate, a derivative of carvacrol, in mice. MAIN METHODS The anti-inflammatory activity was evaluated using various phlogistic agents that induce paw edema, peritonitis model, myeloperoxidase (MPO) activity, pro and anti-inflammatory cytokine levels. Evaluation of antinocicep...

It has long been established that histamine plays a role as a mediator of inflammation. From numerous studies, it has been well known that the amine has many pharmacological actions on a variety of organs. To evaluate the role of histamine in pain perception, we generated HDC knockout mice using a gene targeting method. Histamine is a hydrophilic autacoid, and in most tissues it is stored and s...

The present study was designed to evaluate both anti-inflammatory and antinociceptive activity of the ethanolic extract of dried leaves of Mitragyna parvifolia (MPEE), using the Carrageenan-induced paw edema method in rats and Tail-flick method in mice, respectively, at various dose levels. The maximum antiinflammatory effect of the extract was found to be at 300 mg/kg in carrageenan test and t...

Implication for health policy/practice/research/medical education: PRF was initially regarded as a method of blocking nociceptive stimuli that is less destructive than a thermolesion. Since the introduction of the intra-articular application this concept has changed. PRF is now thought to have an anti-inflammatory effect on the immune system, acting on the nociceptive process itself instead of...