OBJECTIVES This study was designed to evaluate the synergistic antibacterial effect of xylitol and ursolic acid (UA) against oral biofilms in vitro. MATERIALS AND METHODS S. mutans UA 159 (wild type), S. mutans KCOM 1207, KCOM 1128 and S. sobrinus ATCC 33478 were used. The susceptibility of S. mutans to UA and xylitol was evaluated using a broth microdilution method. Based on the results, com...

Staphylococcus epidermidis is one of the most important opportunistic pathogens in nosocomial infections. The main pathogenicity associated with S. epidermidis involves the formation of biofilms on implanted medical devices, biofilms dramatically decrease the efficacy of conventional antibiotics and the host immune system. This emphasizes the urgent need for designing novel anti-staphylococcal ...

OBJECTIVES There is growing evidence to suggest that biofilms may be involved in the aetiology of chronic wounds. The development of formulations with enhanced anti-biofilm activity could therefore represent a potential therapeutic strategy by reducing bioburdens. Here, the antimicrobial properties of ionic silver and sodium hexametaphosphate (polyphosphate) against bacteria in planktonic form ...

Pseudomonas aeruginosa is a highly versatile opportunistic pathogen and its ability to produce biofilms is a direct impediment to the healing of wounds and recovery from infection. Interest in anti-microbial peptides (AMPs) has grown due to their potential therapeutic applications and their possible use against antibiotic resistant bacteria. LL-37 is the only cathelicidin expressed by humans. I...

Legionnaires' disease is a potentially fatal pneumonia caused by Legionella pneumophila, an aquatic bacterium often found within the biofilm niche. In man-made water systems microbial biofilms increase the resistance of legionella to disinfection, posing a significant threat to public health. Disinfection methods currently used in water systems have been shown to be ineffective against legionel...

Biofilms are bacterial communities embedded in exopolymeric substances that form on the surfaces of both man-made and natural structures. Biofilm formation industrial water systems such as cooling towers results biofouling biocorrosion poses a major health concern well an economic burden. Traditionally, biofilms treated with alternating doses oxidizing non-oxidizing biocides, but resistance inc...

background and purpose: today, treatment of life-threatening fungal infections, caused by candida species, has become a major problem. in the present study, we aimed to evaluate the antifungal susceptibility patterns of different clinical candida isolates, determine the virulence factors in multi-drug resistant (mdr) candida species, and assess the anti-biofilm activity of elettaria cardamomum ...

A chemically diverse library of TAGE-triazole conjugates was synthesized utilizing click chemistry on the TAGE scaffold. This library of small molecules was screened for anti-biofilm activity and found to possess the ability of inhibiting biofilm formation against Acinetobacter baumannii, Staphylococcus aureus and Pseudomonas aeruginosa. One such compound in this library demonstrated the most p...

With an epidemic increase in obesity combined with an ageing population, chronic wounds such as diabetic foot ulcers, pressure ulcers and venous leg ulcers are an increasing clinical concern. Recent studies have shown that bacterial biofilms are a major contributor to wound bioburden and interfere with the normal wound healing process; therefore, rational design of wound therapies should includ...