The use of normal bone marrow (granulocyte-macrophage colony-forming units) as a point of reference to normalize the in vitro activities of anticancer agents has been investigated. The cytotoxic effects of four substituted anthraquinone derivatives, and of vinblastine on myeloid progenitors of different donors were reproducible up to a cell kill of approximately 60%. Equitoxic in vitro concentr...

[reaction: see text] The synthesis of a molecular wire bearing an anthraquinone core and thioacetyl end groups for gold electrode binding is described. A model anthraquinone system, substituted with tert-butylthio groups, can be reversibly switched electrochemically from cross conjugated (low conductance "off") to linear conjugated (high conductance "on") via two-electron reduction/oxidation re...

The pod of Cassia fistula Linn. has been used as a laxative drug in Thai traditional medicine for a long time. The pods and leaves contain anthraquinone aglycones and anthraquinone glycosides which are the active laxative form, while rhein is a major component. The degree of laxative potency is depended on the content of anthraquinone glycosides. This study determined the content of total anthr...

Musty "off-flavor" in pond-cultured channel catfish (Ictalurus punctatus) costs the catfish production industry in the United States at least 30 million US dollars annually. The cyanobacterium Oscillatoria perornata (Skuja) is credited with being the major cause of musty off-flavor in farm-raised catfish in Mississippi. The herbicides diuron and copper sulfate, currently used by catfish produce...

In August 1995 the development of a new bird repellent, Flight Control containing anthraquinone, was initiated. A series of laboratory formulation testing, cage and pen studies were conducted. The anthraquinone discrimination threshold (concentration at which birds could detect the test material) for starlings (Sturnus vulgaris) was 151 ppm in treated feeds. The model revealed that to achieve 9...

Binding affinities of ten polycyclic aromatic hydrocarbons to albumin were determined: anthracene, its eight oxy-derivatives: anthraquinone, 9-anthracenemethanol, 9-anthraldehyde, 9-anthracenecarboxylic acid, 1,4-dihydroxyanthraquinone, 1,5-dihydroxyanthraquinone, 1,8-dihydroxyanthraquinone, 2,6-dihydroxyanthraquinone and benzo[a]pyrene. The quenching of albumin fluorescence was used to measure...

Anthraquinone (9,10-anthraquinone) and several hydroxy derivatives, including purpurin (1,2,4-trihydroxyanthraquinone), anthrarufin (1,5-dihydroxyanthraquinone), and chrysazin (1,8-dihydroxyanthraquinone), were evaluated for antioxidative and anti-inflammatory activities in chemical assays and mammalian cells (murine macrophage RAW 264.7 cells). Several tests were used to assess their activitie...

Literature survey revealed that a good number of anthracene and substituted anthracences are potential lasing organic compounds. As per Mitsuo Maeda 9,10 dimethyl and 9,10 diphenyl anthracenes exhibit lasing properties around, 435-450nm. In continuation of our studies27 it was proposed to synthesize new lasing organic dyes in particular, new anthracene derivatives and study their photophysical ...

The formal intramolecular photoredox reaction initially discovered for the parent 2-(hydroxymethyl)anthraquinone (1) in aqueous solution has been extended to a variety of anthraquinones derivatives 6-13, to explore the generality of the reaction, and to investigate its potential utility as a photodeprotecting chromophore. In addition, the related diketone 14 was studied to investigate the need ...