BackgroundImmunosuppression after surgery is associated with postoperative complications, mediated in part by catecholamines that exert anti-inflammatory effects via the β-adrenergic receptor. Phenylephrine, generally regarded as a selective α-adrenergic agonist, frequently used to treat perioperative hypotension. However, phenylephrine may impair host defence through affinity.MethodsHuman leuk...

Chemotherapy-induced peripheral neuropathy is a severe clinical problem frequently associated with cisplatin use. Although its pathophysiology poorly understood, it known that kinin receptors and the transient receptor potential ankyrin 1 (TRPA1) channel play significant role in induced by rodents. However, of signalling pathways downstream from B2 activation sensitisation TRPA1 remains unknown...