The main aim of the present study was to investigate the effects of dietary trans-10, cis-12-conjugated linoleic acid (t10c12-CLA) on intestinal microbiota composition and SCFA production. C57BL/6 mice (n 8 per group) were fed a standard diet either supplemented with t10c12-CLA (0·5 %, w/w) (intervention) or with no supplementation (control), daily for 8 weeks. Metabolic markers (serum glucose,...

This is the protocol of a study aiming to assess the impact of conjugated linoleic acid (CLA) on body mass and composition, carbohydrate and fat digestion and absorption, total energy expenditure, lipid profi le, polyunsaturated fatty acids levels, markers of endothelial dysfunction and mineral status in humans. Seventyfour adult volunteers (BMI ≥ 25 kg/m) will be randomized to receive 3.0 g of...

An article we wrote for the 1998 Illinois Dairy Report (Can Milk Fat be Beneficial to Your Health?) provided a brief description of conjugated linoleic acid (CLA), a minor component of milk fat. Briefly, CLA is a fatty acid that is synthesized in the rumen during biohydrogenation of linoleic acid (C18:2), the predominant fatty acid in vegetable oils. The pathway of biohydrogenation is C18:2 ? C...

The human health aspects of dietary fatty acids have been in the focus of nutritional studies. Several experiments have revealed that dietary conjugated linoleic acid (CLA) has anticancer activity, antiartherogenic effects, reduces body fat gain and enhances immune responses (PARIZA et al., 2000). The term CLA refers to a group of positional and geometric isomers of linoleic acid. The cis-9, tr...

Conjugated linoleic acid (CLA) is a naturally occurring dietary trans fatty acid found in food from ruminant sources. One specific CLA isomer, 10E,12Z-CLA, has been associated with health benefits, such as reduced adiposity, while simultaneously promoting deleterious effects, such as systemic inflammation, insulin resistance, and dyslipidemia. The precise mechanisms by which 10E,12Z-CLA exerts ...

Conjugated fatty acids have attracted much attention as a novel type of biologically beneficial functional lipid. Some isomers of conjugated linoleic acid (CLA) reduce carcinogenesis, atherosclerosis, and body fat. Considering the use of CLA for medicinal and nutraceutical purposes, a safe isomer-selective process is required. The introduction of biological reactions for CLA production could be...