PURPOSE To identify familial aggregation of primary open angle glaucoma (POAG) in first-degree relatives in Shanghai, China. METHODS This was a prospective case-control study. First-degree relatives of 113 POAG patients and 119 normal controls underwent a standardized ophthalmic examination. Each participant was diagnosed as normal, glaucoma suspect or glaucoma. The prevalence of glaucoma and...

This study aims to assess the effectiveness of ganglion cell-inner plexiform layer (GCIPL) measurements in preperimetric glaucoma (PPG) and primary open angle glaucoma (POAG). GCIPL and retinal nerve fiber layer (RNFL) thickness were measured in PPG, POAG, and control groups. The data obtained from these three groups were compared with analysis of variance and post hoc Tukey test. Average GCIPL...

Received for publication November’ 2010 .................................. Purpose: To compare intraocular pressure (IOP) control and post operative complications after trabeculectomy with Mitomycin-C (MMC) in patients with primary open angle glaucoma (POAG) and primary angle-closure glaucoma (PACG). Material and Methods: Sixty patients of both genders with age range of 40 to 70 years, fulfilli...

INTRODUCTION Primary open-angle glaucoma (POAG) is a leading cause of visual impairment worldwide and a complex genetic disorder that affects mostly adults. Mutations in the MYOCILIN (MYOC) and OPTINEURIN genes account for rare forms with a Mendelian inheritance and for <5% of all POAG cases. The CYP1B1 gene, a member of the cytochrome P450 gene family, is a major cause of primary congenital gl...

Glaucoma, the leading cause of irreversible blindness world wide, affecting about 70 million people, 2 is characterised by progressive loss of optic nerve axons and visual field damage. As the condition is insidious, the diagnosis is often missed and the disease detected only later when patients have severe and irreversible visual impairment. Adult primary open angle glaucoma (POAG) is a major ...

AIM To determine (i) the prevalence of glaucoma in people aged > or =50 years, (ii) the proportions of different types of glaucoma, (iii) the distributions of intraocular pressure and vertical cup disc ratio. METHOD Population based prevalence survey in rural West Bengal. People aged > or =50 years in randomly selected villages in 24 Parganas South district. The main outcome measures were dia...

Glaucoma, the leading cause of irreversible blindness world wide, affecting about 70 million people, 2 is characterised by progressive loss of optic nerve axons and visual field damage. As the condition is insidious, the diagnosis is often missed and the disease detected only later when patients have severe and irreversible visual impairment. Adult primary open angle glaucoma (POAG) is a major ...

PURPOSE To compare moderate and advanced glaucoma patients in Ghana. METHODS A retrospective cross-sectional study of 164 patients with primary open-angle glaucoma (POAG) were separated into moderate and advanced glaucoma groups. Definitions of moderate and advanced POAG were derived from International Geographical and Epidemiologic Ophthalmology criteria and included clinical assessment of o...

MMP (Matrix metalloproteinase) 9 is reported to affect glaucoma pathogenesis by altering intraocular pressure (IOP) through its role in remodeling the extracellular matrix (ECM) in the trabecular meshwork. A genetic variant at the promoter region in the MMP9 gene (-1562C>T) has a putative role in regulating its transcription rate and hence can affect genetic predisposition to primary glaucoma. ...

Background Glaucoma, the second leading cause of blindness, affects approximately 64.3 million individuals worldwide. In China, demographic ageing is in rapid progress. Yet detailed and up-to-date estimates of the scale of glaucoma are rare. We aimed to quantify and understand the prevalence and burden of glaucoma in China from 1990 to 2015, with projections until 2050. Methods For this syste...