We studied the role of the sino-aortic baroreceptors in the gradual development of hypertension induced by prolonged administration of small amounts of angiotensin II (A II) in intact dogs and dogs with denervated sino-aortic baroreceptors. Short-term 1-hour infusions of A II(1.0-100 ng/kg per min) showed that conscious denervated dogs had twice the pressor sensitivity of intact dogs. Long-term...

To determine whether prostaglandins contribute to the depressor response to the converting enzyme inhibitor, captopril, we measured the plasma prostaglandin levels by radioimmunoassy before and after captopril administration, and then examined the effect of prostaglandin synthetase inhibition on captopril's antihypertensive effect. When a single oral captopril dose (25-100 mg) was given to 31 s...

The mechanism of action of peptide inhibitors on angiotensin I-converting enzyme (Al-converting enzyme) was studied in relation to the substrate requirements of the enzyme in vivo in the dog lung and in vitro in plasma. l-</-Asp-8-Ile-AI prepared by the solid-phase technique was compared with the known peptide inhibitors of Al-converting enzyme. BPP5il (Pyr-Lys-Trp-Ala-Pro) and SQ 20881 (Pyr-Tr...

Duchenne muscular dystrophy (DMD) is a degenerative disorder affecting skeletal and cardiac muscle for which there is no effective therapy. Angiotension receptor blockade (ARB) has excellent therapeutic potential in DMD based on recent data demonstrating attenuation of skeletal muscle disease progression during 6-9 months of therapy in the mdx mouse model of DMD. Since cardiac-related death is ...

Blood pressure is regulated dynamically by arterial wall tensions in vivo, but the previous methods did not clarify their detailed mechanisms in living animals due to the lack of visualization technique. Thus we aimed to visualize cell kinetics during artery contractions processes by combining in vivo multi-photon imaging and photochemical reaction technique by laser injuries. We recently devel...

BACKGROUND Autophagy is required for the maintenance of cardiomyocyte homeostasis. However, excessive autophagy plays a maladaptive role in pressure overload-induced heart failure. To identify mechanisms by which Stachydrine inhibits pressure overload-induced cardiac hypertrophy, we determined inhibitory activities against activation of NADPH oxidase, reactive oxygen species(ROS) production and...

the hypertensive process in the rat. Circ Res 39: 433-441, 1976 24. Mohring J: High arterial pressure versus humoral factors in the pathogenesis of the vascular lesions of malignant hypertension: The case for humoral factors as well as pressure. Clin Sci 52: 113-117, 1977 25. Bloom DS, Stein MG, Rosendorff C: Effects of hypertensive plasma on the response of an isolated artery preparation to no...