Analysis of clonality by X chromosome inactivation has proven to be a powerful strategy in the study of neoplastic and preneoplastic disorders (P. J. Fialkow, Biochim. Biophys. Acta, 458: 283-321, 1976; B. Vogelstein et al., Cancer Res., 47: 4806-4813, 1987). Recently, the gene for the androgen receptor has been shown to be a highly polymorphic locus in which methylation of DNA correlates with ...

X-linked spinal and bulbar muscular atrophy (SBMA) is a rare form of motor neuron degeneration linked to a CAG repeat expansion in the first exon of the androgen receptor gene coding for a polyglutamine tract. In order to investigate the properties of the SBMA androgen receptor in neuronal cells, cDNAs coding for a wild-type (19 CAG repeats) and a SBMA mutant androgen receptor (52 CAG repeats) ...

Prostate cancer (PCa) is the most prevalent in Nigerian male population, similar to other black populations. It postulated that exposure endogenous or environmental steroids prompts prostatic mediated changes via steroid receptors as well a decrease androgen/estrogen ratio and aging. Thereby contributing carcinogenesis disease progression. This study aimed determine plasma levels of testosteron...

In prostate cancer, androgen/androgen receptor (AR) and their downstream targets play key roles in all stages of disease progression. The protein kinase D (PKD) family, particularly PKD1, has been implicated in prostate cancer biology. Here, we examined the cross-regulation of PKD1 by androgen signaling in prostate cancer cells. Our data showed that the transcription of PKD1 was repressed by an...

Prostate cancer is the most frequent non–skin cancer in men. Although the mechanisms involved in the progression of prostate cancer are not entirely understood, androgen receptor has been shown to play an important role. Androgen receptor is expressed in both early and late-stage prostate cancer. Also, androgen-regulated pathways are thought to be active as evidenced by elevated levels of prost...

The course of rnammalian sexual differentiation is largely under the control of the principal male gonadal steroid, the androgen testosterone. Despite the importance of androgens in the rnediation of sexual differentiation, the molecular basis of androgenic activity in the central nervous system remains poorly characterized. Calcitonin gene-related peptide (CGRP) has previously been reported to...

The androgen receptor is an androgen-dependent transcription factor that belongs to the nuclear superfamily. When not bound its ligand, it mainly localized in cytoplasm, chaperone proteins, which stabilizes inactive conformation and confers a high affinity for ligand. conformational change of begins when molecule binds receptor, subsequently homodimerizes actively translocated nucleus. In nucle...