What is the relation between creativity and psychopathology? Does psychopathology facilitate creativity? Does creative activity induce psychopathology? We expose here an historical bibliographic review, in search of responses to these questions posed from ancient Greece to these days. For Plato, talent was the enthusiasm which drags one away from oneself. For Aristotle, creativity was a rationa...

BACKGROUND Traumatic dental injury (TDI) could have physical and psychosocial consequences for children. Thus, it is important to measure the impact of TDI on the quality of life of children (QoL). The aim of the present study was to investigate the association between treated/untreated TDI and the impact on the quality of life of 11-to-14-year-old Brazilian schoolchildren. METHODS A cross-se...

A conformationally altered prelatent form of antithrombin that possesses both anticoagulant and antiangiogenic activities is produced during the conversion of native to latent antithrombin (Larsson, H., Akerud, P., Nordling, K., Raub-Segall, E., Claesson-Welsh, L., and Björk, I. (2001) J. Biol. Chem. 276, 11996-12002). Here, we show that the previously characterized prelatent antithrombin is a ...

We have previously shown that systemic treatment with the somatostatin analog octreotide has marked beneficial effects on renal function in rats with liver cirrhosis induced by common bile duct ligation (CBL; Jonassen TEN, Christensen S, Sørensen AM, Marcussen N, Flyvbjerg A, Andreasen F, and Petersen JS. Hepatology 29: 1387-1395, 1999). In the present study, we tested the hypothesis that octre...

We perform a first-principles calculation of the quantum-limited laser linewidth, testing the predictions of recently developed theories of the laser linewidth based on fluctuations about the known steady-state laser solutions against traditional forms of the Schawlow-Townes linewidth. The numerical study is based on finite-difference time-domain simulations of the semiclassical Maxwell-Bloch l...

As is well known, the “conventional wisdom” that successful parasites have to become benign is not based on exact evolutionary analysis. Rather than minimizing virulence, selection works to maximize a parasite’s reproduction ratio (see Box 9.1). If the rate of transmission is linked to virulence (defined here as increased mortality due to infection), then selection may in some circumstances lea...

Modeling engineering systems requires creativity and ingenuity , and therefore involves steps that are hardly suitable for automation. However, these steps are complemented by a multitude of routine tasks. Automation of these routine tasks, if tailored to complement non-automated tasks, allows the modeler to focus on the creative and innovative aspects of modeling and design. To this end, three...

BACKGROUND Statistical models based on item response theory were used to examine (a) the performance of individual Positive and Negative Syndrome Scale (PANSS) items and their options, (b) the effectiveness of various subscales to discriminate among individual differences in symptom severity, and (c) the appropriateness of cutoff scores recently recommended by Andreasen and her colleagues (2005...

Can the therapeutic benefits of creativity explain its documented association with psychopathology (Andreasen, 1987; Ludwig, 1995)? Past research seems to have devoted most of its attention to another hypothesis in order to explain this relationship: that features of some disorders may be beneficial for creative cognition (especially in the arts)—for example, the racing thoughts, energy, and op...

Zena Werb mechanism could explain how the shedding of L-selec-tin and syndecan can occur within minutes upon cell Department of Anatomy University of California, San Francisco stimulation. Through these diverse mechanisms, adhesion , deadhesion, and ECM proteolysis are all brought San Francisco, California 94143-0750 to bear at the leading edge of migrating and invading cells where dynamic chan...