Little is known about the tertiary structure of internal ribosome entry site (IRES) elements. The central domain of foot-and-mouth disease (FMDV) IRES, named 3 or I, contains a conserved GNRA motif, essential for IRES activity. We have combined functional analysis with RNA probing to define its structural organization. We have found that a UNCG motif does not functionally substitute the GNRA mo...

In the present issue of Critical Care, an article by Okumura and colleagues has been published on the problem of secondary contamination following chemical agent release [1]. The authors' draw on first-hand experience [2–5] of the secondary contamination experienced during the Tokyo sarin release in 1995. This experience is important, both for the care of contaminated patients and for the safet...

Research focused on preparing new type curing pigment, which called Nitroso-hemoglobin prepared by use of by-products (beef blood), and its application prospect substitutes of nitrite, because of its a poisonous reagent, and can produce carcinogenic nitrosamine after reacting with amine and lead to carcinogenicity, nitrosamines toxicity in meet's product, and this project defined the developmen...

Background: Studies on efficacy of various vaccines that prevent or reduce the primary and recurrent HSV-1 infection have demonstrated the importance of cellular immunity for protection against the infection. We previously used DNA vaccination to induce cellular immunity against HSV-1 infection in mice. Objective: The aim of our study was to evaluate the effect of LIGHT, a member of TNF super f...

− This work introduces a significant extension to the method of p-cycles for network protection. The main advance is the generalization of the p-cycle concept to protect multi-span segments of contiguous working flow, not only spans that lie on the cycle or directly straddle the p-cycle. This effectively extends the p-cycle technique to include path protection or protection of any flow segment ...

Infection of mice with Salmonella typhimurium results in systemic infection and a disease similar to that seen in humans after infection with S. typhi. The innate immune system can restrict replication of S. typhimurium to a certain degree, but for effective control and eradication of bacteria, acquired immunity is essential. Salmonella infection induces the generation of specific CD4+ and CD8+...

abstract   extract prepared from aerial part of pycnocycla spinosa is a relaxant of rat ileum contractions. the objective of this research was to study the spasmolytic activity of p. spinosa root extract for comparison with the aerial part extract. hydroalcoholic extracts were prepared by percolation method. a portion of rat ileum was removed and suspended under 1 g tension in tyrode’s solution...

Each year since 1948, when the Social Security Adtninistration began its studies of income-loss protection from sickness, public and private measures to provide sick or disabled workers with a temporary substitute income have expanded. In 1948 benefit payments amounted to an estimated $0.8 billion and represented 16 p’ercent of the estimated income loss of $4.7 billion. By 1956, benefits had re...

Treated wastewater may be considered as a ‘new’ water resource, which can be added to the general water balance of a region. This ‘new’ source can substitute conventional water used for irrigation. Israel is presently reusing more than 65% of the total domestic sewage production of the country, and it is planned to reach more than 90% reuse during the next decade. This paper addresses the intro...

It is evident that there is a nuclear skills shortage within the UK, and logically it can be assumed that the shortfall extends to the radiation protection arena. Plans for nuclear new-build and the decommissioning of existing nuclear sites will require many more people with radiological knowledge and practical competencies. This converts to a nuclear industry requirement in the order of 1000 n...