the present study was carried out to evaluate the antioxidant and free radical scavenging activity of methanolic extract of ervatamia coronaria leaves (apocynaceae) in various systems. dpph radical, superoxide anion radical, nitric oxide radical and hydroxyl radical scavenging assays were carried out to evaluate the antioxidant potential of the extract. the antioxidant activity of methanolic ex...

Ab initio calculations using the 6-311G**, cc-pVDZ, and (valence) double-zeta pseudopotential (DZP) basis sets, with (MP2, QCISD, CCSD(T)) and without (HF) the inclusion of electron correlation, and density functional (BHandHLYP, B3LYP) calculations predict that the transition states for the reaction of acetyl radical with several alkyl halides adopt an almost collinear arrangement of attacking...

The 1,2,4-benzotriazine 1,4-dioxides are an important class of potential anticancer drugs that selectively kill the low-oxygen (hypoxic) cells found in solid tumors. These compounds undergo intracellular one-electron enzymatic reduction to yield an oxygen-sensitive drug radical intermediate that partitions forward, under hypoxic conditions, to generate a highly reactive secondary radical that c...

1,2-Bis-boronic esters are useful synthetic intermediates particularly as the two boronic can be selectively functionalized. Usually, less hindered primary ester reacts, but herein, we report a coupling reaction that enables reversal of this selectivity. This is achieved through formation boronate complex with an electron-rich aryllithium which, in presence electron-deficient aryl nitrile, lead...

Cryptochrome is a blue light receptor that acts as a sensor for the geomagnetic field and assists many animals in long-range navigation. The magnetoreceptor function arises from light-induced formation of a radical pair through electron transfer between a flavin cofactor (FAD) and a triad of tryptophan residues. Here, this electron transfer is investigated by quantum chemical and classical mole...

Indian Ber contain good source of ascorbic acid and total phenolics. Despite being rich in antioxidants it is an underutilized fruit. Effect of processing on antioxidant activity of ber fruit was studied. Antioxidant activity of ber fruit was evaluated by different methods viz. DPPH radical activity, reducing power assay, superoxide anion radical activity, TBARS, total phenolic content and tota...

The first catalytic intermolecular 1,2-alkylborylation reaction via a radical-relay mechanism between unactivated olefins, bis(pinacolato)diboron, and an alkyl electrophile is reported. Successful implementation of this method requires that the competing boryl substitution retarded to facilitate radical relay. This challenge was overcome using electronically or sterically demanding electrophile...