Elevated cAMP levels in B-cell precursor acute lymphoblastic leukemia (BCP-ALL) cells attenuate the doxorubicin-induced p53 accumulation and protect cells against apoptosis. cAMP responsive element binding protein (CREB) is a cAMP-stimulated transcription factor that regulates genes whose deregulated expression cooperatein oncogenesis. In the present study, we investigated the role of CREB on i...

introduction: meatoplasty is the final and essential step in performing effective canal wall down surgery for chronic otitis media. in this article we review some previous techniques and discuss our preferred method. materials and methods: in this observational case series study, we used this technique in 53 patients (28 male and 25 female) between january 2005 and january 2008. our survey was ...

Objectives: Reading is a language skill based on visual modality which recently is addressed as a facilitator of expressive language in children with Down syndrome. The aim was designing a whole word reading protocol and examining its effects on the language skills of children with Down syndrome. Methods: A whole word reading protocol was developed and was examined through a single-subject s...

Objectives:The expression levels of heat shock proteins (HSPs) are elevated in many cancers, and this overexpression is often associated with both a poor survival and a therapeutic outcome. Curcumin is an anti-cancer agent that also induces a heat shock response. HSPs confer resistance to curcumin-induced apoptosis in cancerous cells. The aim of the current study was to analyze variations in th...

Introduction: Emotional stimulus is processed automatically in a bottom-up way or can be processed voluntarily in a top-down way. Imaging studies have indicated that bottom-up and top-down processing are mediated through different neural systems. However, temporal differentiation of top-down versus bottom-up processing of facial emotional expressions has remained to be clarified. The present st...

objectives: down syndrome (ds) is the most common multiple congenital anomaly syndrome associated with a developmental disability. children with down syndrome have delay in both motor and mental age. this study carried out to explore relationship between mental and motor age of children with ds. methods: a cross-sectional study was conducted on 60 participants with ds (5 to 7 years old) using r...

objective neuromuscular characteristics in down syndrome result in generalized muscular hypotonia, developmental delays and sensory integration deficits. the aim of this study was to compare the effects of simultaneous sensory stimulations and current occupational therapy approaches on motor functions development of infants with down syndrome. materials & methods eighteen infants with down synd...

Chronic lymphocytic leukaemia (CLL) is the most common B-cell malignancy in the western world and exists as subtypes with very different clinical courses. Myeloid cell leukemia 1 (Mcl-1) is one member of Bcl-2 family proteins that has been shown to be expressed in various tissues and malignant cells, including CLL, where its expression is significantly associated with a failure to achieve compl...

Objectives: Down syndrome is a genetic disorder that causes many problems for the affected person and his or her family. The present study aimed to investigate the effect of resilience training on the stress of mothers of students with Down syndrome. Methods: This study is a non-randomized clinical trial conducted on 36 mothers of students with Down syndrome studying at Shahid Rajaieh School, ...