Goals of care discussions, including those focused on code status, are meant to foster autonomous decision making. Unfortunately, these discussions often conflate decisions regarding the use of cardiopulmonary resuscitation for cardiac arrest and mechanical ventilation for prearrest respiratory failure. They also exclude discussions of outcomes, particularly those associated with prearrest resp...

Department of Radiology, Institute of Reumatology in Warsaw1 Kierownik: prof. dr hab. i. sudoł-szopińska Department of Imaging Diagnostics, II Division of Medicine, Warsaw Medical University2 Kierownik: prof. dr hab. w. jakubowski Department of Early Arthritis, Institute of Reumatology in Warsaw3 Kierownik: dr hab. B. kwiatkowska, prof. nadzw. Department of General Surgery, Subdivision of Proct...

Author(s): Don Howard Reviewed work(s): Source: Philosophy of Science, Vol. 71, No. 5, Proceedings of the 2002 Biennial Meeting of The Philosophy of Science AssociationPart II: Symposia PapersEdited by Sandra D. Mitchell (December 2004), pp. 669-682 Published by: The University of Chicago Press on behalf of the Philosophy of Science Association Stable URL: http://w...

Thioredoxin 1 (Trx1) facilitates the reduction of signaling molecules and transcription factors by cysteine thiol-disulfide exchange, thereby regulating cell growth and death. Here we studied the molecular mechanism by which Trx1 attenuates cardiac hypertrophy. Trx1 upregulates DnaJb5, a heat shock protein 40, and forms a multiple-protein complex with DnaJb5 and class II histone deacetylases (H...

Objective Earlier research suggests that birth weight may be associated with celiac disease (CD), but the direction of association has been unclear potentially due to confounding effect from genetic and intrafamilial factors. Through within-twin analyses, we aimed to minimize confounding effects such as twins that share genetic and early environmental exposures. Materials and methods Using th...

Tyrosine kinase activity of the asymmetric EGFR homodimer is negatively regulated via ERK-mediated phosphorylation of Thr-669 in the juxtamembrane domain. In the present study, we investigated in human breast cancer cells whether a similar mechanism plays a role in the feedback regulation of the ErbB2/ErbB3 heterodimer, the most potent ErbB receptor dimer. Constitutive tyrosine phosphorylation ...

We give an efficient algorithm which determines whether a condition due to Hoffman (1963) is satisfied by the cost matrix of a transportation problem. In case the condition is satisfied, our algorithm generates a permutation of the matrix entries *Supported in part by Allon Fellowship and by a Bat Sheva de Rothschild grant. ‘Supported in part by the National Science Foundation under grant ECS-G...

This research aims to analyse the moderating role of household income in relationship between social exclusion and well-being. A multiple-group analysis was conducted determine effect income. The study sample included 669 people who participated labour market Kocaeli; were recruited using convenience sampling. findings showed a significant negative correlation higher for those below hunger thre...

MicroRNAs (miRNAs) are involved in the regulation of multiple cellular processes. Changes of miRNA expression have been linked to the development of various diseases including cancer, but the molecular events leading to these changes at different physiological conditions are not well characterized. Here we examined the intracellular events responsible for the miR-466h-5p activation in mouse cel...