OBJECTIVE To compare the acute toxicity of common injection and sustained-release preparation of norcantharidin for mice so as to identify the attenuation of the sustained-release preparation of norcantharidin. METHODS The poloxamer 407 was used as a sustained-release vehicle for topical administration of norcantharidin, and the acute toxicity of mice treated with common injection and sustain...

Abstract Introduction There are claims by traditional medicine practitioners in Nigeria and valuable scientific reports that the leaves of Tephrosia vogelii (TV) hook used for treatment various diseases; however, there is paucity information on it management cardiovascular complications despite rich presence phytochemicals. This study aimed at investigating effects solvents extracts TV stem lip...

BACKGROUND Estimates of health problems of the elderly in developing countries are required from time to time to predict trends in disease burden and plan health care for the elderly. Developing countries have a poor track record of equitable distribution of health care. Marginalized groups living in urban slums and rural villages have poor penetration of health services. AIMS To identify the...

Crystals of intact small ribosomal subunits from Thermus thermophilus have been obtained from functionally active particles. The crystals (P42(1)2, 407 A x 407 A x 171 A) are suitable for X-ray crystallography analysis to 9.9 A using synchrotron radiation at cryotemperature. Crystallographic data from native and a potential heavy-atom derivative have been collected.

Classically, a computation operates on a string of bits, applying a sequence of physically realizable operations (such as logical NOT, AND, and OR), and outputs an answer based on the value of the last obtained bit string. Similarly, a quantum computation operates on a register consisting of a number of quantum bits (qubits), applying a sequence of (hypothetically) physically realizable quantum...

Do we have non-relativizing techniques? Yes, we do! In fact, already the proof of the CookLevin theorem is non-black-box: to reduce the computation of a nondeterministic TM on a given input x to a 3-cnf φx, we had to “open up” the TM and look inside at the sequence of configurations the TM goes through, and moreover, exploit a very special property of a TM computation: that the computation is l...

Abstract Aim to study the early and long-term outcomes of abdominal wall reconstruction (AWR) complex incisional hernias. Material & Methods We retrospectively reviewed prospectively collected data from 121 patients with 1 7 years follow-up, who underwent midline AWR between 2015 2022. The complexity hernia was determined according criteria N. J. Slater et all. All had a gate width ≥10cm (W...

s 2008;112:407.

BACKGROUND Clostridium difficile infection ranges from mild to severe prolonged diarrhea with systemic symptoms. Previous studies have assessed the correlation of some disease severity parameters to C. difficile ribotypes. However, certain clinical parameters of interest have not yet been evaluated. AIM We conducted an exploratory study to evaluate the correlation of C. difficile ribotypes to...