Purpose: To synthesize and characterize the dextran conjugates of suprofen and flurbiprofen, and also evaluate their biological activities. Methods: Suprofen and flurbiprofen were individually reacted with carbonyldiimidazole to form acylimidazole, which, in turn, was reacted with the dextran of varying molecular weight (40 000, 60 000, and 110 000) to form drug-dextran conjugates. The structur...

Zaltoprofen is a nonsteroidal anti-inflammatory drug used as an analgesic, antipyretic, and antinflammatory agent. It selective COX-2 inhibitor also inhibits bradykinin-induced pain responses without blocking bradykinin receptors. prescribed for treating inflammatory conditions caused by various disorders such dental pain, musculoskeletal postoperative lumbar frozen shoulder, osteoarthritis cer...

Previous phytochemical analysis of methanolic extract of Corallocarpus epigaeus tuber (MCET) has indicated the presence of steroids, flavonoids, glycosides and terpenoid types of compounds. Since these compounds are of pharmacological interest, coupled with the use of this plant in traditional medicine, prompted us to check Corallocarpus epigaeus tubers for possible analgesic anti-inflammatory ...

Direct compression is able to produce tablets at a lower cost than wet granulation and tableting method, due to a fewer items of process validation. In this study, acetaminophen was used as a medicine with various granular diameters to formulate tablets by direct compression, thus evaluating their physical properties. Consequently, direct compression was found effective in formulating tablets w...

The methanol extract of Neolamarckia cadamba (Family: Rubiaceae) barks showed significant analgesic, anti-inflammatory and antipyretic activity. The acute toxicity, orally evaluated in mice, was found to be higher than 3000 mg/kg. The antinociceptive response using writhing and tail immersion test in mice were examined. The antiinflammatory activity using carrageenan and antipyretic activity in...

Emorfazone (4-ethony-2-methyl-5) morpholino(2H-Pyrodazinone) is a nonacidic anti-inflammatory analgesic preparation with a new chemical structure selected from a series of pyridazinone den yates. It is an effective analgesic, anti-inflammatory and anti pyretic drug in animal models, as well as in humans however, the efficacy of this drug on post-surgical dental pain and inflammation is lacking....

BACKGROUND The common cold and other viral airway infections are highly prevalent in the population, and their treatment often requires the use of medications for symptomatic relief. Paracetamol is as an analgesic and antipyretic; chlorphenamine is an antihistamine; and phenylephrine, a vasoconstrictor and decongestant. This randomized, double-blind, placebo-controlled trial sought to evaluate ...

In Thailand, the leaves of Aquilaria crassna have been used traditionally for the treatments of various disorders, but without any scientific analysis. In this study, the antipyretic, analgesic, anti-inflammatory and anti-oxidative properties of A. crassna leaves extract were investigated at a wide dose range in rodents. Experimental animals were treated orally with an aqueous extract of Aquila...

In the present study, p-amino phenol (PAP) and p-amino benzoic acid (PABA) have been modified as lipids palmitoyl p-amino phenol (PPAP) and palmitoyl N p-amino benzoic acid (N-PPABA) by a simple amide formation reaction of the respective compounds with palmitoyl chloride. On screening PPAP and N-PPABA for pharmacological activity, PPAP (an analogue of paracetamol) has been found to exhibit pote...