A patient with Portuguese familial amyloid polyneuropathy who developed haemarthroses secondary to pathological fractures is described. Amyloid material was demonstrated on bone biopsy and confirmed immunohistochemically to be transthyretin (prealbumin). Although amyloid deposits in bone have been described in other types of amyloid, this is believed to be the first proved case of amyloid depos...

Alzheimer’s disease is the most common form of dementia and the generation of oligomeric species of amyloid-b is causal to the initiation and progression of it. Amyloid-b oligomers bind to the N-terminus of plasma membrane-bound cellular prion protein (PrP) initiating a series of events leading to synaptic degeneration. Composition of bound amyloid-b oligomers, binding regions within PrP, bindi...

Amyloid-β (Aβ) self-assembly into cross-β amyloidfibrils is implicated in a causative role in Alzheimer’s disease pathology.Uncertainties persist regarding the mechanisms of amyloid self assembly and the role of metastable prefibrillar aggregates. Aβ fibrilsfeature a sheet-turn-sheet motif in the constituent β-strands; as such, turn nucleation has been proposed as a rate-limiting step in the se...

Introduction: Amyloid diseases have been known to be hereditary, including transthyretin (TTR) amyloidosis where subunit protein mutations may occur in genes for TTR leading to the deposition of fibrils (low molecular weight subunits (5 to 25 kD) of proteins) in extracellular tissues. By reducing the formation of TTR amyloid, diflunisal, a nonsteroidal anti-inflammatory drug (NSAID), has shown ...

AA amyloidosis is a systemic disease that develops secondary to chronic inflammatory diseases Macrophages are often found in the vicinity of amyloid deposits and considered to play a role in both formation and degradation of amyloid fibrils. In spleen reside at least three types of macrophages, red pulp macrophages (RPM), marginal zone macrophages (MZM), metallophilic marginal zone macrophages ...

One of the notable features of Alzheimer's disease (AD) is the overabundance of beta-amyloid peptides in brain fluids, leading to the formation and deposition of insoluble amyloid plaques. Previous work in this lab demonstrates that the normal choroid plexus, a primary component of the blood-cerebrospinal fluid barrier, has the capacity to remove beta-amyloid from the cerebrospinal fluid, poten...

The popular amyloid hypothesis states that beta-amyloid protein aggregates to form sticky deposits in the brain tissue, causing Alzheimer’s disease. Current research studies propose that oligomeric morphologies of beta-amyloid are the principal pathogenic form of the protein. Through the use of a highly-specified capture enzyme-linked immunosorbent assay, the relative quantity of beta-amyloid o...

Joint capsule, meniscus, and cartilage from the patella and medial femoral condyle from 30 non-selected autopsies have been investigated for amyloid deposits with light and electron microscopy. Both right and left knee joints from 28 of the 30 autopsy specimens contained amyloid deposits (93%). The amyloid characteristically showed green dichroism in polarised light after staining with alkaline...

-The resorption of experimental murine amyloidosis induced by Freund's adjuvant was studied over a period of 45 weeks. Three weeks after cessation of the injections splenic amyloid was found in 56-4 per cent of the animals and hepatic amyloid in 10-3 per cent of the animals. Thereafter the incidence of amyloid decreased steadily by the 20th week but splenic amyloid was still present in 14*3 per...