Introduction – In this study we examined brain-behavior correlations in mice using high resolution MRI and 4 different behavioural tests. Secondly, we investigated how these relationships might be altered in Huntington’s disease (HD). For the latter we used YAC 128 mice, a mouse model of HD (1) which recapitulates many of the clinical features and characteristic neuronal changes of HD (2). Meth...

It is the first report that the earlier Alzheimer’s pathological changes can be induced in normal C57BL mice, by B6 deficient feeding for 3 month, and this pathological changes were completely inhibited by anti-homocysteic acid antibody. According to Koch’s postulate, if a pathogen of Alzheimer’s disease is administrated to the normal animal, we would observe the Alzheimer’s pathology in the no...

Introduction: Magnetic resonance imaging (MRI) methods offer a host of noninvasive biomarkers to assess neurodegeneration in multiple sclerosis (MS). These include tissue macrostructure or volume and corresponding microstructural attributes such as relaxation, mean diffusivity and anisotropy [1,2]. Due to the presence of lesions, multimodal MRI volume data are usually coaligned and used to segm...

Introduction Evidences from cognitive neuroscience have found that there are some regions preferentially respond to faces, such as fusiform gyrus, inferior occipital gyrus, superior temporal gyrus, amygdale and parts of the frontal lobe. Haxby have proposed that these regions construct a distributed network for face perception [1]. The theory of distributed network is supported by some recent s...

In a recent article, Blair (1) addresses the neurobiological mechanisms underlying psychopathic traits in childhood. The analysis conducted by the author provides a complete view about the complexity of neuro-functional factors underlying childhood psychopathy. In particular, the author focuses on the role played by structural, endocrinological, genetic, and environmental factors. Surprisingly,...

Objective: Facing an adverse physical or psychosocial situation, an individual is forced to adapt in order to survive. Allostasis is the term used to refer to adapting processes used to maintain the stability of an organism through active processes. When allostatic response is excessive or inefficient, the organism develops an allostatic load. The cascade of molecular and neurobiological effect...

Functional magnetic resonance imaging (fMRI) studies of emotion, personality, and social cognition have drawn much attention in recent years, with high-profile studies frequently reporting extremely high (e.g., >.8) correlations between brain activation and personality measures. We show that these correlations are higher than should be expected given the (evidently limited) reliability of both ...

This paper outlines a study which sought to understand how art therapists structure their approach to treating people who experience borderline personality disorder features. It outlines the understanding of the condition, controversies around diagnosis and its use by evidence based psychological therapies as a guide for structuring therapy. The paper considers how art therapists might utilise ...

Comprehension of information conveyed by emotional tone of speech is highly important for successful social interactions. Regarding the underlying neurobiological mechanisms, successive steps of cerebral processing involving auditory analysis within the temporal cortex and evaluative judgements within the frontal lobes have been differentiated (Schirmer & Kotz, 2006; Wildgruber et al., 2006). T...

Musical processing can be decomposed into the appreciation of global and local elements. This global/local dissociation was investigated with the processing of contourviolated and interval-violated melodies. Performance of a group of 16 children with Williams syndrome and a group of 16 control children were compared in a same-different task. Control participants were more accurate in detecting ...