Antimicrobial peptides (AMPs) are genetically encoded, evolutionarily ancient defence molecule, which act as primary effectors of the innate immune system. Although their origin dates back to the 1920s, research on AMPs has gained momentum relatively recently after the discovery of the underlying mechanisms of innate immunity and their modulation by AMPs. In mammals, the source of AMPs is mainl...

The pathognesis of psoriasis still remains not fully elucidated. Recent advances favor the idea that interactions between innate and adaptive immune response drive inflammatory process in this disease. Innate antimicrobial peptides and proteins (AMPs) are diverse group of small molecules that provide the first line of defense against invading pathogens. In recent years, the novel functions of A...

BACKGROUND The clinical development of antimicrobial peptides (AMPs) is currently under evaluation to combat the rapid increase in MDR bacterial pathogens. However, many AMPs closely resemble components of the human innate immune system and the ramifications of prolonged bacterial exposure to AMPs are not fully understood. OBJECTIVES We show that in vitro serial passage of a clinical USA300 M...

Antarctic Mesoscale Prediction System (AMPS) forecasts of atmospheric moisture and cloud fraction (CF) are compared with observations at McMurdo and Amundsen–Scott South Pole station (hereafter, South Pole station) in Antarctica. Overall, it is found that the model produces excessive moisture at both sites in the midto upper troposphere because of a weaker vertical decrease of moisture in AMPS ...

Antimicrobial peptides (AMPs) are extensive group of molecules that produced by variety tissues of invertebrate, plants, and animal species which play an important role in their immunity response. AMPs have different classifications such as; biosynthetic machines, biological sources, biological functions, molecular properties, covalent bonding patterns, three dimensional structures, and molecul...

The antimicrobial peptide database (APD, http://aps.unmc.edu/AP/) is an original database initially online in 2003. The APD2 (2009 version) has been regularly updated and further expanded into the APD3. This database currently focuses on natural antimicrobial peptides (AMPs) with defined sequence and activity. It includes a total of 2619 AMPs with 261 bacteriocins from bacteria, 4 AMPs from arc...

Antimicrobial peptides (AMPs) are widely expressed and rapidly induced at epithelial surfaces to repel assault from diverse infectious agents including bacteria, viruses, fungi and parasites. Much information suggests that AMPs act by mechanisms that extend beyond their capacity to serve as gene-encoded antibiotics. For example, some AMPs alter the properties of the mammalian membrane or intera...

A study on the relationships of the contents of acid mucopolysaccharides (AMPS), cholesterol, calcium and magnesium in Japanese aortas to the occurrence and severity of intimal disease was performed. A diminished yield of AMPS found with advancing atherosclerosis proved statistically significant. Comparatively, the AMPS content of Japanese aortas in the first six decades was less and the aortic...

BACKGROUND Antimicrobial peptides (AMPs) are synthesized and secreted by immune and epithelial cells that are constantly exposed to environmental microbes. AMPs are essential for barrier defense, and deficiencies lead to increased susceptibility to infection. In addition to their ability to disrupt the integrity of bacterial, viral and fungal membranes, AMPs bind lipopolysaccharides, act as che...

Background: The hematopoietic system is sensitive to the adverse effects of ionizing radiation. Cellular therapies utilizing mesenchymal stem cells or vascular endothelial cells have been explored as potential countermeasures for radiation hematopoietic injuries. We investigated cells cultured from amnion                ...