Aneuploidy is a hallmark of cancer and is associated with malignancy and poor prognosis. Recent studies have revealed that aneuploidy inhibits proliferation, causes distinct alterations in the transcriptome and proteome and disturbs cellular proteostasis. However, the molecular mechanisms underlying the changes in gene expression and the impairment of proteostasis are not understood. Here, we r...

In this study, we compared conventional sperm selection with high-magnification morphology based on the motile sperm organellar morphology examination (MSOME) criteria, and hyaluronic acid (HA) binding for sperm chromosome aneuploidy and DNA fragmentation rates. Semen from 50 severe male factor cases was processed through density gradient centrifugation, and subjected to sperm selection by usin...

ObjectiveTo evaluate whether the telomere length of white blood cells (WBC) and cumulus (CC) in an infertile population is associated with ovarian embryonic performance.DesignProspective cohort study.SettingAcademic-affiliated private practice.PatientsA total 175 women undergoing vitro fertilization (IVF) at a single center between July 2017 December 2018.InterventionsOn day oocyte retrieval, g...

The AMP-activated protein kinase-related kinase (ARK) family comprises 13 proteins, amongst them NUAK1, that can be classified into five subfamilies: AMP-activated protein kinase (AMPK), salt-induced kinase (SIK), microtubule-affinity-regulating kinase (MARK), brain specific kinase (BRSK), and SNF1-like kinase 1 (NUAK). These proteins regulate biological responses such as metabolism, polarity, ...

The mitotic checkpoint is the major cell cycle checkpoint acting during mitosis to prevent aneuploidy and chromosomal instability, which are hallmarks of tumor cells. Reduced expression of the mitotic checkpoint component Mad1 causes aneuploidy and promotes tumors in mice [Iwanaga Y, et al. (2007) Cancer Res 67:160-166]. However, the prevalence and consequences of Mad1 overexpression are curren...

Infertility in humans is surprisingly common occurring in approximately 15% of the population wishing to start a family. Despite this, the molecular and genetic factors underlying the cause of infertility remain largely undiscovered. Nevertheless, more and more genetic factors associated with infertility are being identified. This review will focus on our current understanding of the chromosoma...