miR-17-92 is a microRNA cluster with six distinct members. Here, we show that the miR-17-92 cluster and its individual members modulate chronic neuropathic pain. All cluster members are persistently upregulated in primary sensory neurons after nerve injury. Overexpression of miR-18a, miR-19a, miR-19b and miR-92a cluster members elicits mechanical allodynia in rats, while their blockade alleviat...

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Microarray-based comparative genomic hybridization (M-CGH) is a powerful method for rapidly identifying regions of genome diversity among closely related organisms. We used M-CGH to examine the genome diversity of 17 strains belonging to the nonpathogenic species Bacillus subtilis. Our M-CGH results indicate that there is considerable genetic heterogeneity among members of this species; nearly ...

OBJECTIVE To characterize the clinical phenotype, with an emphasis on electrophysiologic findings, in a family with autosomal dominant retinitis pigmentosa caused by mutation in the recently identified KLHL7 gene. METHODS Eleven patients from a single family were selected from the Swedish retinitis pigmentosa register. Four patients had been examined 13 to 17 years earlier and underwent furth...

a most important phenomenon among organizational resources is creativity along with mobility of staff, while empowerment being the motivator of creativity and mobility. the purpose of this study was an analysis of management and organizational factors necessary for empowerment of iranian agricultural colleges faculty members. research methodology was a descriptive-survey one. the statistical po...

There are countless high mountains in Tibet, and ancient Tibetans believed that gods resided on every one of them. The worship of mountain gods was one of the most important forms of nature worship among ancient Tibetans; it was fundamental to their entire belief system. Each mountain god possessed his own territory and was in charge of particular affairs. Around each god sprang up myths, legen...