We find the gravity duals to an infinite series of N = 3 Chern–Simons quiver theories. They are AdS4 ×M7 vacua of M–theory, with M7 in a certain class of 3–Sasaki–Einstein manifolds obtained by a quotient construction. The field theories can be engineered from a brane configuration; their geometry is summarized by a “hyperKähler toric fan” that can be read off easily from the relative angles of...

Cloned hybridoma cell lines were obtained from fusions of murine myeloma cells with lymphocytes of mice immunized against human breast cancer cells. Hybridomas F36/22 and M7/105 produced antibodies whose binding to breast cancer cells could not be inhibited by prior absorptions with fibroblasts, lymphoblastoid cells, or erythrocytes. Results from cell surface binding assays using a panel of tum...

Chemokines inhibit entry of HIV into CD4(+) T cells more effectively than into macrophages or transfected adherent cells. Here, we tested whether chemokine receptor internalization could account for cell type differences in the effectiveness of chemokines. Infection of CEM T cells expressing stably transduced wild-type CCR5 was much more readily inhibited by chemokine than were transduced HOS c...

We present a new class of solutions of D = 10, N = 2 chiral supergravity. A nonvanishing background for the field strength GMNR of the complex twoform triggers AdS3 × M7 compactifications, where M7 is a 7-dimensional compact manifold. When M7 is a nonsymmetric coset space G/H, we can always find a set of constants GMNR covariantly conserved and thus satisfying the field equations. For example t...

The purpose of this study was to determine whether the two monoclonal anti-cardiac troponin T (cTnT) antibodies (MAbs) used in the second generation cTnT assay by Boehringer Mannheim (BM, capture Ab, M11.7; detection Ab, M7) would detect cTnT isoforms expressed in human skeletal muscle in response to chronic renal disease (CRD). cTnT expression was examined in skeletal muscle biopsies obtained ...

There is an increased risk of leukemia in Down syndrome (DS) patients, with estimates ranging from 14 to 30 times the incidence rate observed for chromosomally normal children. Furthermore, one type of leukemia, called "transient leukemia" (TL), occurs almost exclusively in DS infants. The basis of the association between DS and leukemia is unknown, but we and others have hypothesized that it m...

Patients with acute myeloblastic leukemia (AML) with monosomy 7 are a group of patients with refractory AML who have a very poor prognosis. Therefore, rationally designed new therapies, including metronomic chemotherapy regimen with histidine deacetylase inhibitors (Valporic acid, ATRA) are being investigated as potential treatments for the population of refractory cases of AML. Herein, we repo...

A significant increase in CD25 antigen-positive cells by IL-1 was observed in cells of a patient with M7 acute myelogenous leukemia. Basal proliferation and expression of CD25 antigen by the M7 leukemic cells were inhibited by addition of anti-IL-1 beta antibody in a dose-dependent manner, but not by rabbit anti-IL-1 alpha antibody. Culture supernatants of these leukemic cells contained IL-1 ac...

Objectives: A novel flow cytometric ‘AML Maturity Score (AMS)’ classifying patients into AML-immature (AML-im) and AML-mature (AML-ma) based on CD34, CD117 Tdt expression blasts correlated with induction remission, relapse free survival overall in previous studies. We aimed to study the correlation between AMS ELN risk group outcomes- remission (IR), time (TTR) relapse.
 Material Methods: ...

Oral progestagen treatment extends the weaning-to-estrus interval (WEI) in weaned sows. Particularly in lower parity sows, this allows recovery from lactational catabolism and improves sow productivity. However, the optimal duration of progestagen treatment in contemporary dam-line sows is unclear. Therefore, sows (n = 749) weaned over consecutive 3-wk periods in June and July and classified as...