BACKGROUND Cellulite is the accumulation of subcutaneous fat and connective tissue in tights and buttocks. Xanthines, such as aminophylline, are used as phosphodiesterase inhibitors, and are also adenosine receptor antagonists. OBJECTIVES The aim of the present study was to characterize in vitro aminophylline transdermal absorption through shed snake skin, and to investigate the absorption en...

Protein phosphorylation in cerebral cell-free preparations from neonate rabbits was inhibited by bilirubin and promoted by aminophylline when these substances had been administered intravenously. In animals given both compounds, the bilirubin-induced inhibition of phosphorylation was partly reversed by aminophylline. Adenosine 3',5'-monophosphate added in vitro during the assays also increased ...

Severe asthma is the most common respiratory emergency treated in casualty departments of most hospitals. Intravenous aminophylline has been the mainstay of bronchodilator treatment for several years, although sudden death may occur after rapid administration,1 2 and it may be cardiotoxic.3 We thought that a selective adrenoceptor agonist might therefore be worthy of trial, and we report here o...

The effects of aminophylline given intravenously on the pulmonary circulation and left ventricular performance were studied during combined right and transseptal left heart catheterization in 32 patients with mitral and aortic valvular disease. We recorded complete data on the changes of the pulmonary vascular distending pressure (PD) and the pulmonary blood volume (PBV) before and during amino...

This work investigated the association of acute ethanol and aminophylline administration on behavioral models of depression and prefrontal monoamine levels (i.e. norepinephrine and dopamine) in mice. The animals received a single dose of ethanol (2 g/kg) or aminophylline (5 or 10 mg/kg) alone or in association. Thirty minutes after the last drug administration, the animals were assessed in beha...

Twenty-four patients with reversible airflow obstruction under suboptimal control on conventional therapy entered a double-blind placebo-controlled trial of additional oral sustained release aminophylline. Assessment was by diary cards, twice daily PEFR, and weekly FEV1. Nineteen patients completed the trial satisfactorily. Eleven were improved subjectively by addition of aminophylline. The mea...

The role of phosphodiesterase in glucagon resistance of large adipocytes was investigated. A comparison was made of phosphodiesterase activities of homogenates prepared from isolated small (mean diameter approximately 45 micro m) and large (mean diameter approximately 78 micro m) adipocytes, using various concentrations (5 x 10(-4) to 1 x 10(-7) M) of 3',5'-cAMP. Kinetic analyses revealed two d...

BACKGROUND Retinopathy of prematurity (ROP) is the most common reason behind surgical procedures in premature newborns. Anesthesia in these patients is life-threatening due to post-operative apnea of prematurity (POA). This study aimed to determine the predisposing factors to POA in premature infants and to explore the role of prophylactic aminophylline in decreasing the incidence of POA. MAT...

background: the development of resistance to antimicrobial agents is a major problem in chemotherapy. finding agents which potentiate antimicrobial activity could be favorable. there are some reports that methylxanthines changed the inhibitory effect of antibacterial agents. thus, possible synergistic effect of methylxanthines, aminophylline and caffeine on some antibiotics, carbenicillin, ceft...

the aim of this study was to investigate the prevalence of mg deficiency and effect of aminophylline infusion on urine magnesium concentration after magnesium loading test (mlt). to determine serum mg, venous blood specimens were obtained just before the first mlt. two mlts were performed. the first one was done before starting aminophylline infusion and the 2nd one was done during aminophyllin...