Biginelli-type pyrimidines contain an interesting moiety which has attracted considerable attention of medicinal chemists in the last few decades. Despite the very diverse pharmacologic effects ascribed to this kind of pyrimidines, there are few reports on the antioxidant evaluation of Biginelli pyrimidines. In this study synthesis of some novel Biginelli-type pyrimidines is reported. The prepa...

A series of diverse furo[2,3-d]pyrimidines (2a–2b, 4a–4d and 8a–8c) benzofuro[3,2-d]pyrimidines (12a–12c) were synthesized screened for their antitumor effects against HepG2, Bel-7402 HeLa cell lines in vitro. Representatively, 4a, with an IC50 0.70 ?M, exhibited the best activity tested HepG2 lines. Molecular docking investigation further revealed possible binding modes compound 4a receptor ty...

The properties of natural, y- and yy-pyrimidines are compared using computational (B3LYP, MP2) methods. Ring expansion upon incorporation of benzene or naphthalene into the natural pyrimidines affects the preferred orientation of the base about the glycosidic bond in the corresponding nucleoside to a similar extent. Specifically, although the natural pyrimidines preferentially adopt the anti or...

Pyrimidine nucleotides represent one of the most fundamental of cellular components. They are the building blocks for the direct synthesis of DNA and RNA that function in information storage and retrieval within the cell, but they also participate in the metabolism of a large number of other cellular components from sugar interconversion to cellular polysaccharides to glycoproteins and phosphol...

Suzuki coupling reaction has been often used for the preparation of a diverse set substituted pyrimidines. In this study, 2,4-dichloropyrimidines with aryl and heteroaryl boronic acids was investigated. A thorough screening conditions use microwave irradiation led to very efficient straightforward synthetic procedure providing C4-substituted pyrimidines in good excellent yields. Short time (15 ...

Though the synthesis of riboflavin in large amounts by microorganisms has been encountered, very little is known about the mechani involved in the biosynthesis of this vitamin. A critical examination of the various environmental conditions for different organisms producing this vitamin showed that the optimum conditions for the production of riboflavin varied widely from organism to organism (S...