ATAs engineered for having an enlarged small binding pocket were applied the synthesis of enantiomerically pure (R)-benzo[1,3]dioxol-5-yl-butylamine, a chiral component human leukocyte elastase inhibitor DMP 777 (L-694,458). Kinetic resolution racemic amine was performed by using L59A variant (S)-selective ATA from Chromobacterium violaceum (Cv-ATA), providing residual (R)-enantiomer in excelle...

The present research provides data on the density (ρ), viscosity (η) and ability to absorb carbon dioxide of systems containing amine, molecular solvent (MS) choline chloride (ChCl), with investigation physical properties both neat amine/MS/ChCl mixtures their samples after complete CO2 saturation. effect mixture composition was studied by varying amine from primary (monoethanolamine, MEA) seco...

Nuclear diamination of p-hydrobenzoquinones with aromatic and aliphatic primary amines was catalysed by an immobilised commercial laccase, Denilite II Base, from Novozymes. The amine and the p-hydrobenzoquinone was reacted under mild conditions (at room temperature and at 35 degrees C) in a reaction vessel open to air in the presence of laccase and a co-solvent to afford, exclusively, the diami...

The title compound, C(15)H(15)NO, which was synthesized under solvent-free conditions by the reaction of acetoacetone and 2-naphthyl-amine, adopts a Z conformation about the C=C bond. The enamine-ketone fragment is approximately planar [maximum deviation = 0.026 (3) Å] and forms a dihedral angle of 39.78 (3)° with the naphthalene ring system. An intra-molecular N-H⋯O hydrogen bond is observed.

The title compound, C(16)H(19)NO, was synthesized under solvent-free conditions by reaction of 7-oxa-bicyclo-[4.1.0]heptane and naphthalen-1-amine in the presence of Ca(CF(3)COO)(2) as catalyst. The cyclo-hexane ring adopts a chair conformation. In the crystal, mol-ecules are linked by inter-molecular N-H⋯O hydrogen bonds and C-H⋯π inter-actions into chains parallel to the c axis.

Primary amine-salicylamides derived from chiral trans-cyclohexane-1,2-diamines are used as organocatalysts for the enantioselective conjugate addition of α,α-disubstituted aldehydes to arylated and heteroarylated nitroalkenes. The reaction is performed in the presence of 4-dimethylaminopyridine as an additive in dichloromethane as a solvent at room temperature. The corresponding enantioenriched...

A series of bis(σ-B-H) complexes of copper(i) have been prepared by displacement of arene solvent from a β-diketiminate copper(i) complex by four-coordinate boranes, H3B-L (L = NMe3, lutidine). In the presence of the same copper arene complex, the secondary amine-borane H3B-NMe2H undergoes dehydrogenation. We provide evidence for formation of a heterogengous catalyst from decomposition of the s...

In the hydrogenation of sluggish unactivated enamine substrates, Rh complexes of electron-deficient phosphines are demonstrated to be far more reactive catalysts than those derived from triphenylphosphine. These operate at low catalyst loadings (down to 0.01 mol %) and are able to reduce tetrasubstituted enamines. The use of the sustainable and environmentally benign solvent (R)-limonene for th...

A homogeneous Pd(II) catalyst, utilizing a simple and inexpensive amine ligand (TMEDA), allows 2-alkynoates to be prepared in high yields by an oxidative carbonylation of terminal alkynes and alcohols. The catalyst system overcomes many of the limitations of previous palladium carbonylation catalysts. It has an increased substrate scope, avoids large excesses of alcohol substrate and uses a des...

In the title complex, [Mn(C(36)H(50)N(2)O(2))(CH(3)COO)(H(2)O)]·CH(3)CH(2)OH, the Mn(III) atom is in an octa-hedral environment and is coordinated by the tetra-dentate amine-bis-(phenolate) ligand, a monodentate acetate anion and a water mol-ecule. An ethanol solvent mol-ecule is also found in the asymmetric unit. The structure displays O-H⋯O and C-H⋯O hydrogen bonding.