SUMMARY We report on a major new version of the RMAP software for mapping reads from short-read sequencing technology. General improvements to accuracy and space requirements are included, along with novel functionality. Included in the RMAP software package are tools for mapping paired-end reads, mapping using more sophisticated use of quality scores, collecting ambiguous mapping locations and...

This paper reviews the recent theoretical literature that analyses the European Union’s policy to eliminate preferential corporate tax regimes and the proposal to introduce a consolidated EU tax base with formula apportionment for the taxation of multinational firms. Since neither proposal includes a harmonisation of corporate tax rates, a core issue is how tax competition between member states...

Few studies have examined the role of players in game design. The objective of this paper is to provide some clarity on the issue of player-centred design by analysing the notions on player in current game design literature. This research also discusses the potentials a multifaceted approach on players can offer for the design of games. The article starts by analysing different approaches on pl...

Casual observation suggests that Internet media firms sometimes allow consumers to pay to remove advertisements from a free advertisement-based product. In this paper I characterize when this business model is optimal and analyze its impact on advertising quantity and the distribution of surplus. The optimality of the business model depends on the relation between product quality, the annoyance...

The relationship between trade unions and the unemployed is complex and, to some extent, ambiguous. The article first presents the main features of such a relationship, synthesising evidence from various cases (historical and contemporary). Then, using a Marxist dialectical approach, it looks at the features that characterise trade unions in order to explain why they act as they do towards the ...

To examine whether visual attention shifts continuously across the visual field, we measured sensitivity to a small flash presented at various locations while the observer was tracking a moving target in an ambiguous apparent motion display. The sensitivity peaked near the target and the peak shifted smoothly along the apparent motion path. Since the peak-shift speed varied with the speed of th...

Crisp input and output data are fundamentally indispensable in traditional data envelopment analysis (DEA). However, the real-world problems often deal with imprecise or ambiguous data. In this paper, we propose a novel robust data envelopment model (RDEA) to investigate the efficiencies of decision-making units (DMU) when there are discrete uncertain input and output data. The method is based ...

Background: X-linked lissencephaly with ambiguous genitalia (XLAG) is a recently described genetic disorder, in which patients present with lissencephaly, agenesis of the corpus callosum, refractory epilepsy of neonatal onset, acquired microcephaly, and male genotype with ambiguous genitalia. XLAG is responsible for a severe neurological disorder of neonatal onset in boys. A gyration defect con...