نتایج جستجو برای: alveolar epithelial

تعداد نتایج: 195783  

2011
Vedang A Londhe Tiffany M Maisonet Benjamin Lopez Jade-Ming Jeng Jing Xiao Changgong Li Parviz Minoo

BACKGROUND Alveolar septation marks the beginning of the transition from the saccular to alveolar stage of lung development. Inflammation can disrupt this process and permanently impair alveolar formation resulting in alveolar hypoplasia as seen in bronchopulmonary dysplasia in preterm newborns. NF-κB is a transcription factor central to multiple inflammatory and developmental pathways includin...

Journal: :American journal of respiratory cell and molecular biology 1992
C L Wohlford-Lenane P L Durham J M Snyder

Surfactant is a lipoprotein substance that is synthesized and secreted by alveolar type II epithelial cells and acts to reduce surface tension at the air-alveolar interface. SP-C is a 5,000-D molecular weight, hydrophobic, surfactant-associated protein. In the present study, we used a ribonuclease protection assay to show that SP-C mRNA is induced in rabbit fetal lung tissue early in developmen...

A new series of 1,2-diaryl-4,5,6,7-tetrahydro-1H-benzo[d]imidazoles, possessing trimethoxy phenyl pharmacophore, were synthesized to evaluate their biological activities as tubulin inhibitors. Cytotoxic activity of the synthesized compounds 7a-f was assessed against several human cancer cell lines, including MCF-7 (breast cancer cell), HEPG2 (liver hepatocellular cells), A549 (adenocarcinomic h...

Journal: :JCI insight 2016
Yan Xu Takako Mizuno Anusha Sridharan Yina Du Minzhe Guo Jie Tang Kathryn A Wikenheiser-Brokamp Anne-Karina T Perl Vincent A Funari Jason J Gokey Barry R Stripp Jeffrey A Whitsett

Idiopathic pulmonary fibrosis (IPF) is a lethal interstitial lung disease characterized by airway remodeling, inflammation, alveolar destruction, and fibrosis. We utilized single-cell RNA sequencing (scRNA-seq) to identify epithelial cell types and associated biological processes involved in the pathogenesis of IPF. Transcriptomic analysis of normal human lung epithelial cells defined gene expr...

Journal: :American journal of physiology. Lung cellular and molecular physiology 2012
Bernard J Fisher Donatas Kraskauskas Erika J Martin Daniela Farkas Jacob A Wegelin Donald Brophy Kevin R Ward Norbert F Voelkel Alpha A Fowler Ramesh Natarajan

Bacterial infections of the lungs and abdomen are among the most common causes of sepsis. Abdominal peritonitis often results in acute lung injury (ALI). Recent reports demonstrate a potential benefit of parenteral vitamin C [ascorbic acid (AscA)] in the pathogenesis of sepsis. Therefore we examined the mechanisms of vitamin C supplementation in the setting of abdominal peritonitis-mediated ALI...

2017
Kuan Li Qi Wu Xin Sun Yan Geng Dong Leng Hongwei Li Subei Zhang Qiaoxing Wang Junping Wu Long Xu Xue Li Yu Li Qiuyang Zhang Adrianne Kurkciyan Jiurong Liang Dianhua Jiang Huaiyong Chen

An aberrant systemic artery supply results in recurrent infections in the abnormal lung lobe of intralobar pulmonary sequestration (ILS). The mechanisms underlying such persistent inflammation are unknown. Here, we hypothesize that alteration of an endothelial cell niche for alveolar epithelial cells results in the impaired proliferation potential of alveolar progenitor cells, leading to the de...

2017
Hai B Tran Hubertus Jersmann Tung Thanh Truong Rhys Hamon Eugene Roscioli Miranda Ween Melissa R Pitman Stuart M Pitson Greg Hodge Paul N Reynolds Sandra Hodge

INTRODUCTION We have previously established a link between impaired phagocytic capacity and deregulated S1P signaling in alveolar macrophages from COPD subjects. We hypothesize that this defect may include a disruption of epithelial-macrophage crosstalk via Spns2-mediated intercellular S1P signaling. METHODS Primary alveolar macrophages and bronchial epithelial cells from COPD subjects and co...

Journal: :PLoS Medicine 2005
Annie Pardo Kevin Gibson José Cisneros Thomas J Richards Yinke Yang Carina Becerril Samueal Yousem Iliana Herrera Victor Ruiz Moisés Selman Naftali Kaminski

BACKGROUND Idiopathic pulmonary fibrosis (IPF) is a progressive and lethal disorder characterized by fibroproliferation and excessive accumulation of extracellular matrix in the lung. METHODS AND FINDINGS Using oligonucleotide arrays, we identified osteopontin as one of the genes that significantly distinguishes IPF from normal lungs. Osteopontin was localized to alveolar epithelial cells in ...

2002
Annie Pardo Moisés Selman

1. Abstract 2. Introduction 3. Lessons from the inflammatory pathway 3.1. The paradigm of type 1 or type 2 cytokine network commitment 3.2. Chemokines 3.2.1. Chemokines in inflammatory/fibrotic lung disorders 3.2.2. Chemokines and Th1/Th2 cytokines circuit 3.2.3. Chemokines and angiogenesis 4. The epithelial pathway. Tying loose ends 4.1. Idiopathic pulmonary fibrosis and the alveolar epitheliu...

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