background: vitamin d (vit d) is linked to various conditions including musculoskeletal, metabolic and   cardiopulmonary diseases. however, it is not clear whether correction of vit d deficiency exerts any beneficial effect in patients with pulmonary hypertension. methods: this study was a prospective uncontrolled longitudinal study. patients with pulmonary hypertension and vit d deficiency wer...

chylothorax in adult occurs most commonly in the wake of cardiac and thoracic procedures. injuries to the  common thoracic duct in the thorax or its branches in the mediastinum, injuries to the thymus tissues, dissection of the superior vena cava or ascending aorta, dissection of the aortic arch, disruption of the accessory lymphatics in the left or right thorax, and increased pressure in the s...

• At elevations above 10,000 feet alveolar hypoxia leads to pulmonary arterial hypertension, arterial hypoxemia, and secondary polycythemia in most persons.' The adjustments of adults to this hypoxic environment have been extensively studied but there is relatively little information pertaining to neonates and young children. The only published catheterization study on young children at high al...

With rising altitude the partial pressure of oxygen falls. This phenomenon leads to hypobaric hypoxia at high altitude. Since more than 140 million people permanently live at heights above 2500 m and more than 35 million travel to these heights each year, understanding the mechanisms resulting in acute or chronic maladaptation of the human body to these circumstances is crucial. This review sum...

Right-heart failure (RHF) due to pulmonary hypertension, more commonly known as brisket disease or high altitude disease, is a complex disease that is becomingly increasing problematic for the cattle industry–regardless of altitude. The disease became known as high altitude disease because until the mid-1960s RHF was only reported at altitudes over 7,000 ft. Today, RHF is still problematic in h...

Said, Sami I. Mediators and modulators of pulmonary arterial hypertension. Am J Physiol Lung Cell Mol Physiol 291: L547–L558, 2006. First published May 12, 2006; doi:10.1152/ajplung.00546.2005.—Pulmonary hypertension (PH), defined as a mean pulmonary arterial (PA) pressure of 25 mmHg at rest or 30 mmHg during exercise, is characterized by a progressive and sustained increase in pulmonary vascul...

In the 1960s, studies on lungs of normal, high altitude dwelling natives demonstrated distinct structural differences in the pulmonary vasculature, compared to native sea level dwellers, accompanied by mild pulmonary hypertension [1]. ARIAS-STELLA and SALDANA [2] reported an increase in medial muscle mass in the distal segments of the pulmonary arterial tree. This was considered not to be due t...