The objective of this study was to determine the relationship between body weight (BW) and heart girth (HG) in Sardi and Timahdite sheep in order to develop a prediction equation of BW from HG. The data used for this study included 476 records on BW and HG (227 in Sardi and 249 in Timahdite) collected on males and females of different ages in 33 private farms. The BW and the HG averaged 34.8 ± ...

Two genetic lines of barrows and gilts with different lean growth rates were used to determine the BW and chemical composition growth from 23 to 125 kg of BW. The experiment was a 2 x 2 x 5 factorial arrangement of treatments in a completely randomized design conducted in 2 replicates. Six pigs from each sex and genetic line were killed at approximately 25-kg intervals from 23 kg to 125 kg of B...

The appropriateness of relying on the coefficient of determination (r) as a statistical metric for judging the predictability of human clearance (CL) based on interspecies animal data was assessed. An explicit mathematical expression was derived for r as a function of species body weight and the corresponding measured value of CL. The derived mathematical function demonstrated that r is numeric...

Abstract. A model of the radionuclide accumulation in fish taking into account contribution different tissues and allometry is presented. The basic assumptions are as follows. (i) organism represented by several compartments which radionuclides homogeneously distributed. (ii) correspond to three groups organs or tissues: muscle, bones (kidney, liver, gonads, etc.) differing metabolic function. ...

TO THE EDITOR—We thank Dr Pai for highlighting the importance of optimal dosing of polymyxins [1]. As described in our original paper [2], a number of commonly used approaches to account for body size were extensively evaluated via population modeling and covariate analysis. These body size models included allometric and linear scaling by both total body weight (TBW) and lean body weight (LBW),...

Understanding the concept of extrapolation of dose between species is important for pharmaceutical researchers when initiating new animal or human experiments. Interspecies allometric scaling for dose conversion from animal to human studies is one of the most controversial areas in clinical pharmacology. Allometric approach considers the differences in body surface area, which is associated wit...